Tbio TCF12 Transcription factor 12

Protein Summary

Description

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99081
• B4E1W1
• Q7Z3D9
• Q86TC1
• Q86VM2
• TCF-12

Gene Name

• TCF12

Ensembl ID

• ENST00000267811
• ENSP00000267811
• ENSG00000140262
• ENST00000333725
• ENSP00000331057
• ENST00000343827
• ENSP00000342459
• ENST00000438423
• ENSP00000388940
• ENST00000537840
• ENSP00000444696
• ENST00000557843
• ENSP00000453737

Symbol

• BHLHB20
• HEB
• HTF4
• HEB
• p64
• CRS3
• HTF4
• TCF-12
• bHLHb20
• HsT17266

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
transcription factor perturbation	0.98
kinase perturbation	0.96
molecular function	0.93
transcription factor	0.92

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Transcription Factor 12

Protein / Nucleic Acid Binding / Transcription Factor 12

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Transcription Factor 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.46   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 314   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.46   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0