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Tbio
TCF12
Transcription factor 12

Protein Summary
Description
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267811
  • ENSP00000267811
  • ENSG00000140262
  • ENST00000333725
  • ENSP00000331057
  • ENST00000343827
  • ENSP00000342459
  • ENST00000438423
  • ENSP00000388940
  • ENST00000537840
  • ENSP00000444696
  • ENST00000557843
  • ENSP00000453737

Symbol
  • BHLHB20
  • HEB
  • HTF4
  • HEB
  • p64
  • CRS3
  • HTF4
  • TCF-12
  • bHLHb20
  • HsT17266
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
transcription factor perturbation
0.98
kinase perturbation
0.96
molecular function
0.93
transcription factor
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.74   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.74   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
2
2
98.2
mean platelet volume
3
3
3
90.6
3
3
2
1.1
86.5
testosterone measurement
2
1
2
82.9
insomnia measurement
1
1
0
1
69.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
98.2
mean platelet volume
3
90.6
2
1.1
86.5
testosterone measurement
2
82.9
insomnia measurement
0
1
69.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor 12
VGNC:13428
453466
Macaque
transcription factor 12
699626
Mouse
MGI:101877
21406
Rat
RGD:3829
25720
Dog
transcription factor 12
VGNC:47189
100684199
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor 12
Macaque
transcription factor 12
Mouse
Rat
Dog
transcription factor 12
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99081-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Myogenesis
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Myogenesis
RNA Polymerase II Transcription
Gene Ontology Terms (27)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
BHF-UCL
Protein-Protein Interactions (156)
1 – 10 of 156
FERD3L
Tbio
Family: TF
Novelty: 0.06797434
p_int: 0.999999966
p_ni: 3.4e-8
Score: 0.855
Data Source: BioPlex,STRINGDB
MYF6
Tbio
Family: TF
Novelty: 0.00509046
p_int: 0.999999926
p_ni: 7.4e-8
Score: 0.979
Data Source: BioPlex,STRINGDB
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
p_int: 0.999999611
p_ni: 3.89e-7
Score: 0.584
Data Source: BioPlex,STRINGDB
NEUROD1
Tbio
Family: TF
Novelty: 0.00188624
p_int: 0.999999585
p_ni: 4.15e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
HAND2
Tbio
Family: TF
Novelty: 0.00478924
p_int: 0.999999299
p_ni: 7.01e-7
Score: 0.49
Data Source: BioPlex,STRINGDB
HEXIM2
Tbio
Novelty: 0.14814693
p_int: 0.999998769
p_ni: 0.000001231
Score: 0.552
Data Source: BioPlex,STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
p_int: 0.999998672
p_ni: 0.000001328
Score: 0.999
Data Source: BioPlex,STRINGDB
ID2
Tbio
Family: TF
Novelty: 0.00256364
p_int: 0.999997212
p_ni: 0.000002788
Score: 0.831
Data Source: BioPlex,STRINGDB
TWIST2
Tbio
Family: TF
Novelty: 0.00748285
p_int: 0.99999437
p_ni: 0.00000563
p_wrong: 1e-9
Score: 0.591
Data Source: BioPlex,STRINGDB
MYOG
Tbio
Family: TF
Novelty: 0.00074867
p_int: 0.999990796
p_ni: 0.000009204
Score: 0.991
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  238.74

PubMed score by year
PubTator Score  133.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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