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Tbio
HBEGF
Proheparin-binding EGF-like growth factor

Protein Summary
Description
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230990
  • ENSP00000230990
  • ENSG00000113070

Symbol
  • DTR
  • DTS
  • HEGFL
  • DTR
  • DTS
  • DTSF
  • HEGFL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.94
kinase perturbation
0.93
gene perturbation
0.92
small molecule perturbation
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1044.06   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1044.06   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
2
1
5.6
65.6
white matter integrity
2
1
2
44.9
creatine kinase measurement
1
1
1
15
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
5.6
65.6
white matter integrity
2
44.9
creatine kinase measurement
1
15
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heparin binding EGF like growth factor
VGNC:6931
735979
Macaque
heparin binding EGF like growth factor
695559
Mouse
MGI:96070
15200
Rat
RGD:2526
25433
Dog
heparin binding EGF like growth factor
VGNC:41609
607007
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heparin binding EGF like growth factor
Macaque
heparin binding EGF like growth factor
Mouse
Rat
Dog
heparin binding EGF like growth factor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99075-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (85)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 57
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (168)
1 – 10 of 168
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.993
Data Source: Reactome,STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.989
Data Source: Reactome,STRINGDB
ERBB4
Tclin
Family: Kinase
Novelty: 0.00112919
Score: 0.989
Data Source: Reactome,STRINGDB
BTC
Tbio
Novelty: 0.00673076
Score: 0.983
Data Source: Reactome,STRINGDB
EREG
Tbio
Novelty: 0.00371897
Score: 0.982
Data Source: Reactome,STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.977
Data Source: Reactome,STRINGDB
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
Score: 0.968
Data Source: STRINGDB
ADAM17
Tchem
Family: Enzyme
Novelty: 0.00121971
Score: 0.966
Data Source: Reactome,STRINGDB
NRG1
Tbio
Novelty: 0.00095246
Score: 0.96
Data Source: Reactome,STRINGDB
NRG2
Tbio
Novelty: 0.01986994
Score: 0.957
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1044.06

PubMed score by year
PubTator Score  440.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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