You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CSF3R
Granulocyte colony-stimulating factor receptor

Protein Summary
Description
Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331941
  • ENSP00000332180
  • ENSG00000119535
  • ENST00000361632
  • ENSP00000355406
  • ENST00000373103
  • ENSP00000362195
  • ENST00000373104
  • ENSP00000362196
  • ENST00000373106
  • ENSP00000362198

Symbol
  • GCSFR
  • SCN7
  • CD114
  • GCSFR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.75
PubMedID
0.71
biological term
0.69
disease
0.63
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.35   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 620   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.35   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 620   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
4
6
93.4
myeloid white cell count
2
2
3
91.3
leukocyte count
3
3
5
78.2
neutrophil percentage of leukocytes
2
2
3
72.2
lymphocyte percentage of leukocytes
2
2
3
70.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
6
93.4
myeloid white cell count
3
91.3
leukocyte count
5
78.2
neutrophil percentage of leukocytes
3
72.2
lymphocyte percentage of leukocytes
3
70.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
colony stimulating factor 3 receptor
VGNC:511
456756
Macaque
colony stimulating factor 3 receptor
713485
Mouse
MGI:1339755
12986
Rat
RGD:1309114
298518
Dog
colony stimulating factor 3 receptor
VGNC:39658
607605
Species
Name
OMA
EggNOG
Inparanoid
Chimp
colony stimulating factor 3 receptor
Macaque
colony stimulating factor 3 receptor
Mouse
Rat
Dog
colony stimulating factor 3 receptor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99062-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (392)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Developmental Biology
Immune System
Other interleukin signaling
Signaling by Interleukins
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (162)
1 – 10 of 162
CSF3
Tbio
Novelty: 0.00011283
Score: 0.993
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.95
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.926
Data Source: STRINGDB
CSF2
Tbio
Novelty: 0.00010437
Score: 0.873
Data Source: STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00164278
Score: 0.871
Data Source: STRINGDB
SPI1
Tbio
Family: TF
Novelty: 0.00064309
Score: 0.846
Data Source: STRINGDB
IL3
Tbio
Novelty: 0.0002336
Score: 0.823
Data Source: STRINGDB
SOCS3
Tbio
Novelty: 0.00106095
Score: 0.798
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.789
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.772
Data Source: STRINGDB
Publication Statistics
PubMed Score  262.35

PubMed score by year
PubTator Score  288.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: