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Tbio
RMDN3
Regulator of microtubule dynamics protein 3

Protein Summary
Description
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260385
  • ENSP00000260385
  • ENSG00000137824
  • ENST00000338376
  • ENSP00000342493

Symbol
  • FAM82A2
  • FAM82C
  • PTPIP51
  • RMD3
  • RMD-3
  • FAM82C
  • FAM82A2
  • ptpip51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.96
cell type or tissue
0.73
transcription factor binding site profile
0.69
co-expressed gene
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.99888352
p_ni:  0.00111648
Score:  0.919
Data Source:  BioPlex,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.990386843
p_ni:  0.009613157
Data Source:  BioPlex
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.973350817
p_ni:  0.026649183
Score:  0.543
Data Source:  BioPlex,STRINGDB
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.953445591
p_ni:  0.046554409
Data Source:  BioPlex
SLC7A14
Tbio
Family:  Transporter
Novelty:  0.1613451
p_int:  0.945108125
p_ni:  0.054891875
Data Source:  BioPlex
RMDN2
Tbio
Novelty:  0.10425524
p_int:  0.812182677
p_ni:  0.187817323
Score:  0.91
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.810847023
p_ni:  0.189152977
Score:  0.8
Data Source:  BioPlex,STRINGDB
PTPN1
Tchem
Family:  Enzyme
Novelty:  0.00065779
Score:  0.82
Data Source:  STRINGDB
RPUSD2
Tdark
Family:  Enzyme
Novelty:  1.41606982
Score:  0.736
Data Source:  STRINGDB
GCHFR
Tbio
Family:  Enzyme
Novelty:  0.04287433
Score:  0.703
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
79.2
mean corpuscular volume
1
1
1
74.4
waist-hip ratio
1
1
1
42.3
sex hormone-binding globulin measurement
1
1
1
31.4
triglyceride measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
79.2
mean corpuscular volume
1
74.4
waist-hip ratio
1
42.3
sex hormone-binding globulin measurement
1
31.4
triglyceride measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of microtubule dynamics 3
VGNC:13419
467657
Macaque
regulator of microtubule dynamics 3
703902
Mouse
MGI:1915059
67809
Rat
RGD:1308697
311328
Dog
regulator of microtubule dynamics 3
VGNC:45607
487497
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of microtubule dynamics 3
Macaque
regulator of microtubule dynamics 3
Mouse
Rat
Dog
regulator of microtubule dynamics 3
Publication Statistics
PubMed Score 33.72
PubMed score by year
PubTator Score 33.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title