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Tbio
FAM129B
Niban-like protein 1

Protein Summary
Description
May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373312
  • ENSP00000362409
  • ENSG00000136830
  • ENST00000373314
  • ENSP00000362411

Symbol
  • C9orf88
  • OC58
  • MEG-3
  • C9orf88
  • MINERVA
  • bA356B19.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
protein complex
0.99
transcription factor perturbation
0.88
transcription factor binding site profile
0.79
transcription factor
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
4
94.2
testosterone measurement
2
2
2
75
systolic blood pressure
1
1
1
39.3
platelet count
1
1
1
21
platelet crit
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
94.2
testosterone measurement
2
75
systolic blood pressure
1
39.3
platelet count
1
21
platelet crit
1
13.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 129 member B
VGNC:4689
464748
Macaque
family with sequence similarity 129 member B
707403
Mouse
MGI:2442910
227737
Rat
RGD:1307018
362115
Dog
family with sequence similarity 129 member B
VGNC:40590
609251
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 129 member B
Macaque
family with sequence similarity 129 member B
Mouse
Rat
Dog
family with sequence similarity 129 member B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96TA1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (24)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (17)
1 – 10 of 17
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.999990726
p_ni: 0.000009086
p_wrong: 1.88e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.999979341
p_ni: 0.000020625
p_wrong: 3.5e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
KEAP1
Tclin
Novelty: 0.00062812
Score: 0.63
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.626
Data Source: STRINGDB
FAM83H
Tbio
Novelty: 0.02527211
Score: 0.57
Data Source: STRINGDB
OR8G1
Tdark
Family: oGPCR
Novelty: 9.20634921
Score: 0.557
Data Source: STRINGDB
ZNF777
Tdark
Family: TF
Novelty: 1.20195224
Score: 0.547
Data Source: STRINGDB
RAI14
Tbio
Novelty: 0.06291577
Score: 0.523
Data Source: STRINGDB
FAM3C
Tbio
Novelty: 0.04598347
Score: 0.507
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.31

PubMed score by year
PubTator Score  41.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer