Tbio GPHA2 Glycoprotein hormone alpha-2

Protein Summary

Description

Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258). GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q96T91
• Q52LE2

Gene Name

• GPHA2

Ensembl ID

• ENST00000279168
• ENSP00000279168
• ENSG00000149735
• ENST00000533257
• ENSP00000432918

Symbol

• GPA2
• ZSIG51
• A2
• GPA2
• ZSIG51

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.62
hub protein	0.49
cell type or tissue	0.46
cell line	0.45
metabolite	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.14   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.14   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (144)

Explore Interacting Targets

1 – 10 of 144

• See Interactions on String-DB

FAAP100

Tdark

Novelty:  0.1698504

p_int:  0.99996072

p_ni:  0.00003928

Data Source:  BioPlex

GPT2

Tbio

Family:  Enzyme

Novelty:  0.00478585

p_int:  0.99991993

p_ni:  0.000080033

p_wrong:  3.7e-8

Score:  0.303

Data Source:  BioPlex,STRINGDB

ADGRV1

Tbio

Family:  GPCR

Novelty:  0.01398129

p_int:  0.999438969

p_ni:  0.000561031

Data Source:  BioPlex

EPHA6

Tchem

Family:  Kinase

Novelty:  0.02713974

p_int:  0.983181308

p_ni:  0.000972073

p_wrong:  0.015846619

Score:  0.303

Data Source:  BioPlex,STRINGDB

FRAS1

Tbio

Novelty:  0.02114063

p_int:  0.977878501

p_ni:  0.022121499

Data Source:  BioPlex

PLXNA2

Tbio

Novelty:  0.01765957

p_int:  0.976850304

p_ni:  0.023149696

Data Source:  BioPlex

CNTNAP3

Tbio

Novelty:  0.22791524

p_int:  0.957962596

p_ni:  0.042037404

Data Source:  BioPlex

ADAM9

Tchem

Family:  Enzyme

Novelty:  0.00616626

p_int:  0.942302769

p_ni:  0.057697212

p_wrong:  1.9e-8

Score:  0.173

Data Source:  BioPlex,STRINGDB

ANKRD46

Tbio

Novelty:  0.06546845

p_int:  0.934047609

p_ni:  0.065905526

p_wrong:  0.000046865

Data Source:  BioPlex

LAMB2

Tbio

Novelty:  0.07966931

p_int:  0.836038853

p_ni:  0.163961147

Score:  0.158

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (7)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Hormone ligand-binding receptors	13 targets	R-HSA-375281

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Hormone ligand-binding receptors	13 targets	R-HSA-375281

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (4)

Components (2)

Processes (3)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
protein heterodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
thyrotropin-releasing hormone receptor binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
hormone receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
hormone activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
uric acid measurement	EFO_0004761	1	1	1		69

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
uric acid measurement	EFO_0004761	1		69

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UniProt Keyword Find Similar Targets

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Complete proteome
Disulfide bond
Glycoprotein
Hormone
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
uric acid measurement

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glycoprotein hormone alpha 2	VGNC:11791	744235
Macaque	glycoprotein hormone alpha 2		717261
Mouse	glycoprotein hormone alpha 2	MGI:2156541	170458
Cow	glycoprotein hormone alpha 2	VGNC:29533	617578
Pig	glycoprotein hormone alpha 2		100516058

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glycoprotein hormone alpha 2
Macaque	glycoprotein hormone alpha 2
Mouse	glycoprotein hormone alpha 2
Cow	glycoprotein hormone alpha 2
Pig	glycoprotein hormone alpha 2

Publication Statistics

PubMed Score 101.14

PubMed score by year

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PubTator Score 72.70

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (7)

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10

0 of 0

PMID	Year	Title