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Tbio
SLC9A7
Sodium/hydrogen exchanger 7

Protein Summary
Description
Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis. This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328306
  • ENSP00000330320
  • ENSG00000065923

Symbol
  • NHE7
  • NHE7
  • NHE-7
  • SLC9A6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
histone modification site profile
0.77
cellular component
0.61
virus perturbation
0.59
protein domain
0.58


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.04   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.04   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
69.2
leukocyte count
1
1
1
64.9
hemoglobin measurement
1
1
1
62.1
hematocrit
1
1
1
59
neutrophil percentage of leukocytes
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
69.2
leukocyte count
1
64.9
hemoglobin measurement
1
62.1
hematocrit
1
59
neutrophil percentage of leukocytes
1
29
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A7
VGNC:11644
465595
Macaque
solute carrier family 9 member A7
710906
Mouse
MGI:2444530
236727
Dog
solute carrier family 9 member A7
VGNC:46489
609144
Horse
solute carrier family 9 member A7
VGNC:23283
100060383
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A7
Macaque
solute carrier family 9 member A7
Mouse
Dog
solute carrier family 9 member A7
Horse
solute carrier family 9 member A7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96T83-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium/Proton exchangers
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium/Proton exchangers
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (54)
1 – 10 of 54
SLC9A6
Tbio
Family:  Transporter
Novelty:  0.01410234
p_int:  0.999999996
p_wrong:  4e-9
Score:  0.357
Data Source:  BioPlex,STRINGDB
KRBOX4
Tdark
Novelty:  0.6803597
Score:  0.802
Data Source:  STRINGDB
SLC9B2
Tbio
Family:  Transporter
Novelty:  0.04898001
Score:  0.779
Data Source:  STRINGDB
CHST7
Tbio
Family:  Enzyme
Novelty:  0.18769086
Score:  0.771
Data Source:  STRINGDB
SCAMP2
Tbio
Novelty:  0.05952592
Score:  0.747
Data Source:  STRINGDB
RACK1
Tbio
Novelty:  0.00200617
Score:  0.649
Data Source:  STRINGDB
ZNF674
Tdark
Family:  TF
Novelty:  0.29358331
Score:  0.647
Data Source:  STRINGDB
ZNF41
Tbio
Family:  TF
Novelty:  0.1617438
Score:  0.638
Data Source:  STRINGDB
SCAMP5
Tbio
Novelty:  0.07749456
Score:  0.611
Data Source:  STRINGDB
SCAMP1
Tbio
Novelty:  0.03293648
Score:  0.59
Data Source:  STRINGDB
Publication Statistics
PubMed Score  26.04

PubMed score by year
PubTator Score  9.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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