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Tbio
MMS19
MMS19 nucleotide excision repair protein homolog

Protein Summary
Description
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327238
  • ENSP00000320059
  • ENSG00000155229
  • ENST00000355839
  • ENSP00000348097
  • ENST00000370782
  • ENSP00000359818
  • ENST00000415383
  • ENSP00000395045
  • ENST00000438925
  • ENSP00000412698
  • ENST00000441194
  • ENSP00000413801

Symbol
  • MMS19L
  • CIAO4
  • MET18
  • MMS19L
  • hMMS19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.93
hub protein
0.88
interacting protein
0.87
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.84   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.84   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
CIAO1
Tbio
Novelty:  0.03999673
p_int:  0.99070812
p_ni:  0.00929188
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CDKAL1
Tbio
Family:  Enzyme
Novelty:  0.01013607
p_int:  0.964107686
p_ni:  0.035892314
Score:  0.86
Data Source:  BioPlex,STRINGDB
DNA2
Tbio
Family:  Enzyme
Novelty:  0.00195682
p_int:  0.953974559
p_ni:  0.046025441
Score:  0.91
Data Source:  BioPlex,STRINGDB
FBXL5
Tbio
Novelty:  0.03103624
p_int:  0.892819709
p_ni:  0.107180291
Score:  0.831
Data Source:  BioPlex,STRINGDB
WBP1
Tbio
Novelty:  1.24967974
p_int:  0.882589479
p_ni:  0.11741052
Score:  0.549
Data Source:  BioPlex,STRINGDB
CIAO2B
Tbio
Novelty:  0.09725962
p_int:  0.867618591
p_ni:  0.132381409
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.807432642
p_ni:  0.192567358
Score:  0.635
Data Source:  BioPlex,STRINGDB
CIAO3
Tbio
Novelty:  0.00627147
Score:  0.989
Data Source:  Reactome,STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.987
Data Source:  STRINGDB
NUBP1
Tbio
Novelty:  0.03429412
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic iron-sulfur cluster assembly
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
90.7
monocyte count
1
1
1
78.4
granulocyte percentage of myeloid white cells
1
1
1
40.7
BMI-adjusted waist circumference
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
90.7
monocyte count
1
78.4
granulocyte percentage of myeloid white cells
1
40.7
BMI-adjusted waist circumference
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MMS19 homolog, cytosolic iron-sulfur assembly component
VGNC:7281
450653
Mouse
MGI:1919449
72199
Rat
RGD:727890
171124
Dog
MMS19 homolog, cytosolic iron-sulfur assembly component
VGNC:43293
477788
Horse
MMS19 homolog, cytosolic iron-sulfur assembly component
VGNC:20240
100070717
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MMS19 homolog, cytosolic iron-sulfur assembly component
Mouse
Rat
Dog
MMS19 homolog, cytosolic iron-sulfur assembly component
Horse
MMS19 homolog, cytosolic iron-sulfur assembly component
Publication Statistics
PubMed Score 50.84
PubMed score by year
PubTator Score 21.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title