Tbio MMS19 MMS19 nucleotide excision repair protein homolog

Protein Summary

Description

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242).

Uniprot Accession IDs

• Q96T76
• B0QZ75
• B3KPE5
• B4DQX2
• B4E2I3
• D3DR55
• F8W9Y2
• Q17RZ8
• Q5T455
• Q66K82
• Q7L4W8
• Q969Z1
• Q96DF1
• Q96MR1
• Q96RK5
• Q96SK1
• Q9BUE2
• Q9BYS9
• hMMS19

Gene Name

• MMS19

Ensembl ID

• ENST00000327238
• ENSP00000320059
• ENSG00000155229
• ENST00000355839
• ENSP00000348097
• ENST00000370782
• ENSP00000359818
• ENST00000415383
• ENSP00000395045
• ENST00000438925
• ENSP00000412698
• ENST00000441194
• ENSP00000413801

Symbol

• MMS19L
• CIAO4
• MET18
• MMS19L
• hMMS19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
disease perturbation	0.93
hub protein	0.88
interacting protein	0.87
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Mms19 Nucleotide Excision Repair Protein Homolog

Protein / Nucleic Acid Binding / Mms19 Nucleotide Excision Repair Protein Homolog

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Mms19 Nucleotide Excision Repair Protein Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.95   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.95   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0