Tbio NMNAT3 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Protein Summary

Description

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q96T66
• B3KVR6
• D3DNF2
• D3DNF3
• Q8N4G1
• NMN/NaMN adenylyltransferase 3

Gene Name

• NMNAT3

Ensembl ID

• ENST00000296202
• ENSP00000296202
• ENSG00000163864
• ENST00000339837
• ENSP00000340523
• ENST00000413939
• ENSP00000412953

Symbol

• PNAT3
• FKSG76
• PNAT-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
tissue sample	0.73
histone modification site profile	0.62
pathway	0.6
PubMedID	0.56

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Nicotinamide/nicotinic Acid Mononucleotide Adenylyltransferase 3

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Nicotinamide/nicotinic Acid Mononucleotide Adenylyltransferase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.77   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.77   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0