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Tchem
PNKP
Bifunctional polynucleotide phosphatase/kinase

Protein Summary
Description
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322344
  • ENSP00000323511
  • ENSG00000039650
  • ENST00000596014
  • ENSP00000472300

Symbol
  • PNK
  • AOA4
  • MCSZ
  • EIEE10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.97
ligand (protein) perturbation
0.96
cellular component
0.68
tissue sample
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.46   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.46   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (93)
POLB
Tchem
Family:  Enzyme
Novelty:  0.00145102
p_int:  0.999999609
p_ni:  3.65e-7
p_wrong:  2.6e-8
Score:  0.957
Data Source:  BioPlex,Reactome,STRINGDB
XRCC4
Tbio
Novelty:  0.00305644
p_int:  0.999938688
p_ni:  0.000061312
Score:  0.987
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.999134871
p_ni:  0.000865129
Score:  0.187
Data Source:  BioPlex,STRINGDB
CCDC43
Tdark
Novelty:  0.99040074
p_int:  0.997842788
p_ni:  0.001560457
p_wrong:  0.000596755
Score:  0.516
Data Source:  BioPlex,STRINGDB
HBA1
Tclin
Novelty:  0.00094113
p_int:  0.981875082
p_ni:  0.018124893
p_wrong:  2.5e-8
Data Source:  BioPlex
XRCC1
Tbio
Novelty:  0.00084203
Score:  0.997
Data Source:  Reactome,STRINGDB
LIG3
Tbio
Family:  Enzyme
Novelty:  0.00809038
Score:  0.981
Data Source:  Reactome,STRINGDB
LIG4
Tbio
Family:  Enzyme
Novelty:  0.00412993
Score:  0.978
Data Source:  STRINGDB
XRCC5
Tbio
Novelty:  0.00150735
Score:  0.978
Data Source:  STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (R-HSA-5649702)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome
Base Excision Repair
Reactome
DNA Repair
Reactome
Resolution of Abasic Sites (AP sites)
Name
Explore in Pharos
Explore in Source
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Base Excision Repair
DNA Repair
Resolution of Abasic Sites (AP sites)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
35.5
mathematical ability
1
1
1
11.4
aortic measurement
1
1
1
7.1
platelet count
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
35.5
mathematical ability
1
11.4
aortic measurement
1
7.1
platelet count
1
2.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polynucleotide kinase 3'-phosphatase
VGNC:2440
747683
Macaque
polynucleotide kinase 3'-phosphatase
719084
Mouse
MGI:1891698
59047
Rat
RGD:1303331
308576
Dog
polynucleotide kinase 3'-phosphatase
VGNC:44743
484373
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polynucleotide kinase 3'-phosphatase
Macaque
polynucleotide kinase 3'-phosphatase
Mouse
Rat
Dog
polynucleotide kinase 3'-phosphatase
Publication Statistics
PubMed Score 124.46
PubMed score by year
PubTator Score 120.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title