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Tbio
KCNK16
Potassium channel subfamily K member 16

Protein Summary
Description
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373227
  • ENSP00000362324
  • ENSG00000095981
  • ENST00000373229
  • ENSP00000362326
  • ENST00000425054
  • ENSP00000391498
  • ENST00000437525
  • ENSP00000415375

Symbol
  • TALK1
  • TALK1
  • TALK-1
  • K2p16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
cell line
0.61
gene perturbation
0.53
transcription factor
0.42
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
CCPG1
Tbio
Novelty:  0.07685013
p_int:  0.998051533
p_ni:  0.001948467
Data Source:  BioPlex
UBXN7
Tbio
Novelty:  0.07437638
p_int:  0.996738653
p_ni:  0.002594839
p_wrong:  0.000666508
Score:  0.217
Data Source:  BioPlex,STRINGDB
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
p_int:  0.953277138
p_ni:  0.046708365
p_wrong:  0.000014496
Data Source:  BioPlex
SEC62
Tbio
Novelty:  0.01236418
p_int:  0.935943614
p_ni:  0.064056386
Score:  0.193
Data Source:  BioPlex,STRINGDB
GHDC
Tbio
Novelty:  0.08423152
p_int:  0.931313971
p_ni:  0.068686029
Score:  0.17
Data Source:  BioPlex,STRINGDB
GRAMD1A
Tbio
Novelty:  0.15461113
p_int:  0.911029104
p_ni:  0.088970896
Data Source:  BioPlex
NPLOC4
Tbio
Novelty:  0.01690434
p_int:  0.838557866
p_ni:  0.161442134
Score:  0.163
Data Source:  BioPlex,STRINGDB
TMX2
Tbio
Novelty:  0.09856355
p_int:  0.820791553
p_ni:  0.179130031
p_wrong:  0.000078416
Score:  0.363
Data Source:  BioPlex,STRINGDB
EMC8
Tbio
Novelty:  0.2452967
p_int:  0.807647512
p_ni:  0.143225279
p_wrong:  0.049127209
Score:  0.189
Data Source:  BioPlex,STRINGDB
FNDC3A
Tbio
Novelty:  0.04721453
p_int:  0.802239041
p_ni:  0.197754006
p_wrong:  0.000006953
Score:  0.201
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
3
2
1
1.1
88.7
migraine disorder
2
1
0
1.1
83.3
1
1
1
42.9
mean corpuscular hemoglobin concentration
1
1
1
30.9
intraocular pressure measurement
1
1
1
27.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
1
1.1
88.7
migraine disorder
0
1.1
83.3
1
42.9
mean corpuscular hemoglobin concentration
1
30.9
intraocular pressure measurement
1
27.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 16
VGNC:7897
462667
Macaque
potassium two pore domain channel subfamily K member 16
719585
Mouse
MGI:1921821
74571
Rat
RGD:1582911
688996
Horse
potassium two pore domain channel subfamily K member 16
VGNC:19294
100054147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 16
Macaque
potassium two pore domain channel subfamily K member 16
Mouse
Rat
Horse
potassium two pore domain channel subfamily K member 16
Publication Statistics
PubMed Score 14.79
PubMed score by year
PubTator Score 8.76
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title