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Tbio
KCNK16
Potassium channel subfamily K member 16

Protein Summary
Description
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373227
  • ENSP00000362324
  • ENSG00000095981
  • ENST00000373229
  • ENSP00000362326
  • ENST00000425054
  • ENSP00000391498
  • ENST00000437525
  • ENSP00000415375

Symbol
  • TALK1
  • TALK1
  • TALK-1
  • K2p16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
cell line
0.61
gene perturbation
0.53
transcription factor
0.42
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Protein-Protein Interactions (52)
1 – 10 of 52
CCPG1
Tbio
Novelty: 0.12386545
p_int: 0.998051533
p_ni: 0.001948467
Data Source: BioPlex
UBXN7
Tbio
Novelty: 0.05830904
p_int: 0.996738653
p_ni: 0.002594839
p_wrong: 0.000666508
Score: 0.217
Data Source: BioPlex,STRINGDB
ALG9
Tbio
Family: Enzyme
Novelty: 0.08306637
p_int: 0.953277138
p_ni: 0.046708365
p_wrong: 0.000014496
Data Source: BioPlex
SEC62
Tbio
Novelty: 0.01587362
p_int: 0.935943614
p_ni: 0.064056386
Score: 0.193
Data Source: BioPlex,STRINGDB
GHDC
Tbio
Novelty: 0.14562067
p_int: 0.931313971
p_ni: 0.068686029
Score: 0.17
Data Source: BioPlex,STRINGDB
GRAMD1A
Tdark
Novelty: 0.3099631
p_int: 0.911029104
p_ni: 0.088970896
Data Source: BioPlex
NPLOC4
Tbio
Novelty: 0.02827204
p_int: 0.838557866
p_ni: 0.161442134
Score: 0.163
Data Source: BioPlex,STRINGDB
TMX2
Tbio
Novelty: 0.11413043
p_int: 0.820791553
p_ni: 0.179130031
p_wrong: 0.000078416
Score: 0.363
Data Source: BioPlex,STRINGDB
EMC8
Tdark
Novelty: 1
p_int: 0.807647512
p_ni: 0.143225279
p_wrong: 0.049127209
Score: 0.189
Data Source: BioPlex,STRINGDB
FNDC3A
Tbio
Novelty: 0.00427151
p_int: 0.802239041
p_ni: 0.197754006
p_wrong: 0.000006953
Score: 0.201
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.51

PubMed score by year
PubTator Score  8.76

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFV
1-70
QVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFL
70-140
NHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITL
140-210
STIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSLRQGCGAKAAPG
210-280
RRPRRGSTAARGVQVTPQDFPISKKGLGS
280-309
MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS