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Tbio
KCNK17
Potassium channel subfamily K member 17

Protein Summary
Description
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373231
  • ENSP00000362328
  • ENSG00000124780
  • ENST00000453413
  • ENSP00000401271

Symbol
  • TALK2
  • TASK4
  • TALK2
  • TASK4
  • TALK-2
  • TASK-4
  • K2p17.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
cell type or tissue
0.69
trait
0.61
cell line
0.6
phenotype
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.28   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.28   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
1
1.1
34
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
34
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 17
VGNC:7898
748287
Macaque
potassium two pore domain channel subfamily K member 17
719574
Dog
potassium two pore domain channel subfamily K member 16
481781
Horse
potassium two pore domain channel subfamily K member 17
VGNC:19295
100065439
Cow
potassium two pore domain channel subfamily K member 17
VGNC:30470
282264
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 17
Macaque
potassium two pore domain channel subfamily K member 17
Dog
potassium two pore domain channel subfamily K member 16
Horse
potassium two pore domain channel subfamily K member 17
Cow
potassium two pore domain channel subfamily K member 17
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96T54-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Protein-Protein Interactions (19)
1 – 10 of 19
KCNK18
Tclin
Family: IC
Novelty: 0.01151961
Score: 0.728
Data Source: STRINGDB
KCTD20
Tdark
Novelty: 0.47655751
Score: 0.661
Data Source: STRINGDB
PRSS21
Tbio
Family: Enzyme
Novelty: 0.0110251
Score: 0.61
Data Source: STRINGDB
SLC25A44
Tdark
Family: Transporter
Novelty: 0.36924538
Score: 0.609
Data Source: STRINGDB
RPL36
Tbio
Novelty: 0.02259932
Score: 0.603
Data Source: STRINGDB
KCTD18
Tdark
Novelty: 0.8176728
Score: 0.558
Data Source: STRINGDB
KCNC2
Tclin
Family: IC
Novelty: 0.02509313
Score: 0.55
Data Source: STRINGDB
KCNG2
Tclin
Family: IC
Novelty: 0.31296944
Score: 0.545
Data Source: STRINGDB
CDKAL1
Tbio
Family: Enzyme
Novelty: 0.01013607
Score: 0.543
Data Source: STRINGDB
KCNRG
Tbio
Novelty: 0.09992793
Score: 0.528
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.28

PubMed score by year
PubTator Score  57.55

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer