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Tbio
MBOAT4
Ghrelin O-acyltransferase

Protein Summary
Description
Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320542
  • ENSP00000314196
  • ENSG00000177669

Symbol
  • GOAT
  • OACT4
  • GOAT
  • OACT4
  • FKSG89
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.6
tissue
0.53
gene perturbation
0.5
phenotype
0.42
biological term
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.78   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.78   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
Synthesis, secretion, and deacylation of Ghrelin
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Peptide hormone metabolism
Synthesis, secretion, and deacylation of Ghrelin
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (57)
1 – 10 of 57
GHRL
Tchem
Novelty: 0.00017827
Score: 0.932
Data Source: Reactome,STRINGDB
GHSR
Tclin
Family: GPCR
Novelty: 0.00165638
Score: 0.854
Data Source: STRINGDB
SST
Tbio
Novelty: 0.00005944
Score: 0.653
Data Source: STRINGDB
HHAT
Tbio
Family: Enzyme
Novelty: 0.003077
Score: 0.638
Data Source: STRINGDB
SOAT1
Tchem
Family: Enzyme
Novelty: 0.00530755
Score: 0.625
Data Source: STRINGDB
GPR39
Tchem
Family: GPCR
Novelty: 0.01244607
Score: 0.625
Data Source: STRINGDB
MCHR1
Tchem
Family: GPCR
Novelty: 0.00295097
Score: 0.615
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.597
Data Source: STRINGDB
AGRP
Tbio
Novelty: 0.00147804
Score: 0.584
Data Source: STRINGDB
DGAT1
Tclin
Family: Enzyme
Novelty: 0.00121009
Score: 0.582
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.78

PubMed score by year
PubTator Score  17.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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