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Tchem
MBOAT4
Ghrelin O-acyltransferase

Protein Summary
Description
Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320542
  • ENSP00000314196
  • ENSG00000177669

Symbol
  • GOAT
  • OACT4
  • GOAT
  • OACT4
  • FKSG89
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.6
tissue
0.53
gene perturbation
0.5
phenotype
0.42
biological term
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.49   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.49   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0