Tbio RSF1 Remodeling and spacing factor 1

Protein Summary

Description

Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598). This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q96T23
• Q86X86
• Q9H3L8
• Q9NVZ8
• Q9NYU0
• Rsf-1

Gene Name

• RSF1

Ensembl ID

• ENST00000308488
• ENSP00000311513
• ENSG00000048649
• ENST00000480887
• ENSP00000434509

Symbol

• HBXAP
• XAP8
• XAP8
• p325
• HBXAP
• RSF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
histone modification site profile	0.84
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.81
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Remodeling And Spacing Factor 1

Protein / Transcription Factor / Zinc Finger Transcription Factor / Remodeling And Spacing Factor 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Remodeling And Spacing Factor 1

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Remodeling And Spacing Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.14   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.14   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0