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Tbio
SECISBP2
Selenocysteine insertion sequence-binding protein 2

Protein Summary
Description
Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB. The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339901
  • ENSP00000364959
  • ENSG00000187742
  • ENST00000375807
  • ENSP00000364965
  • ENST00000534113
  • ENSP00000436650

Symbol
  • SBP2
  • SBP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
virus perturbation
0.98
disease perturbation
0.87
transcription factor perturbation
0.68
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.88   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.88   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
EEFSEC
Tbio
Novelty:  0.00847753
Score:  0.997
Data Source:  Reactome,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
Score:  0.979
Data Source:  STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
Score:  0.961
Data Source:  STRINGDB
RPS25
Tbio
Novelty:  0.02812798
Score:  0.909
Data Source:  STRINGDB
RPS13
Tbio
Novelty:  0.0019983
Score:  0.909
Data Source:  STRINGDB
RPL14
Tbio
Novelty:  0.01600377
Score:  0.908
Data Source:  STRINGDB
RPS21
Tbio
Novelty:  0.00578555
Score:  0.908
Data Source:  STRINGDB
RPL12
Tbio
Novelty:  0.01176619
Score:  0.906
Data Source:  STRINGDB
RPS12
Tbio
Novelty:  0.00497802
Score:  0.902
Data Source:  STRINGDB
RPS20
Tbio
Novelty:  0.01018837
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (68)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Selenoamino acid metabolism
Reactome
Selenocysteine synthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Selenoamino acid metabolism
Selenocysteine synthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
5
6
77
reticulocyte measurement
2
2
2
76.7
mean corpuscular volume
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
77
reticulocyte measurement
2
76.7
mean corpuscular volume
1
56.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SECIS binding protein 2
VGNC:4859
464583
Macaque
SECIS binding protein 2
697442
Mouse
MGI:1922670
75420
Rat
RGD:620991
79049
Dog
SECIS binding protein 2
VGNC:45978
476351
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SECIS binding protein 2
Macaque
SECIS binding protein 2
Mouse
Rat
Dog
SECIS binding protein 2
Publication Statistics
PubMed Score 168.88
PubMed score by year
PubTator Score 94.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title