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Tclin
CRBN
Protein cereblon

Protein Classes
Protein Summary
Description
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3. This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231948
  • ENSP00000231948
  • ENSG00000113851
  • ENST00000432408
  • ENSP00000412499

Symbol
  • MRT2
  • MRT2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.97
protein complex
0.93
transcription factor binding site profile
0.73
cellular component
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.04   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.04   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
5
7
98
eosinophil percentage of leukocytes
2
7
7
97.5
basophil percentage of leukocytes
2
5
6
94.2
basophil count
4
5
8
93.5
basophil percentage of granulocytes
1
3
3
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
7
98
eosinophil percentage of leukocytes
7
97.5
basophil percentage of leukocytes
6
94.2
basophil count
8
93.5
basophil percentage of granulocytes
3
91.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cereblon
VGNC:1790
460130
Macaque
cereblon
704436
Mouse
MGI:1913277
58799
Rat
RGD:1310533
297498
Horse
cereblon
VGNC:16851
100052958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cereblon
Macaque
cereblon
Mouse
Rat
Horse
cereblon
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96SW2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (90)
1 – 10 of 90
KHDRBS2
Tbio
Novelty:  0.01986638
p_int:  0.999520777
p_ni:  0.000056255
p_wrong:  0.000422968
Data Source:  BioPlex
TGIF2LY
Tdark
Family:  TF
p_int:  0.999460339
p_ni:  0.000447661
p_wrong:  0.000092001
Data Source:  BioPlex
PDK1
Tchem
Family:  Kinase
Novelty:  0.0078496
p_int:  0.998900553
p_ni:  0.001077012
p_wrong:  0.000022435
Score:  0.234
Data Source:  BioPlex,STRINGDB
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.995320142
p_ni:  0.000191774
p_wrong:  0.004488084
Data Source:  BioPlex
CUL4A
Tchem
Novelty:  0.00917788
p_int:  0.989974102
p_ni:  0.010025898
Score:  0.993
Data Source:  BioPlex,STRINGDB
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.966667163
p_ni:  0.014599138
p_wrong:  0.018733699
Score:  0.549
Data Source:  BioPlex,STRINGDB
CUL4B
Tbio
Novelty:  0.0133075
p_int:  0.960227888
p_ni:  0.039772112
Score:  0.977
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.943713911
p_ni:  0.005477234
p_wrong:  0.050808855
Score:  0.801
Data Source:  BioPlex,STRINGDB
CFP
Tbio
Novelty:  0.00063251
p_int:  0.941797161
p_ni:  0.009356731
p_wrong:  0.048846108
Score:  0.19
Data Source:  BioPlex,STRINGDB
CAVIN1
Tbio
Family:  Enzyme
Novelty:  0.00780634
p_int:  0.811988635
p_ni:  0.000659427
p_wrong:  0.187351937
Score:  0.185
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  336.04

PubMed score by year
PubTator Score  85.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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