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Tbio
OSBPL9
Oxysterol-binding protein-related protein 9

Protein Summary
Description
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361556
  • ENSP00000354970
  • ENSG00000117859
  • ENST00000371714
  • ENSP00000360779
  • ENST00000428468
  • ENSP00000407168
  • ENST00000447887
  • ENSP00000412733
  • ENST00000453295
  • ENSP00000413263
  • ENST00000462759
  • ENSP00000433279
  • ENST00000486942
  • ENSP00000431980
  • ENST00000531828
  • ENSP00000433083

Symbol
  • ORP9
  • OSBP4
  • ORP9
  • ORP-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
transcription factor
0.82
kinase perturbation
0.76
virus perturbation
0.76
transcription factor binding site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.98   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.98   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0