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Tbio
OSBPL9
Oxysterol-binding protein-related protein 9

Protein Summary
Description
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361556
  • ENSP00000354970
  • ENSG00000117859
  • ENST00000371714
  • ENSP00000360779
  • ENST00000428468
  • ENSP00000407168
  • ENST00000447887
  • ENSP00000412733
  • ENST00000453295
  • ENSP00000413263
  • ENST00000462759
  • ENSP00000433279
  • ENST00000486942
  • ENSP00000431980
  • ENST00000531828
  • ENSP00000433083

Symbol
  • ORP9
  • OSBP4
  • ORP9
  • ORP-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
transcription factor
0.82
kinase perturbation
0.76
virus perturbation
0.76
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.41   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.41   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (20)
1 – 10 of 20
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.999999993
p_ni: 3e-9
p_wrong: 4e-9
Score: 0.85
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.999999715
p_ni: 2.83e-7
p_wrong: 2e-9
Score: 0.827
Data Source: BioPlex,STRINGDB
FUZ
Tbio
Novelty: 0.03001976
p_int: 0.999998538
p_ni: 0.000001461
p_wrong: 2e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
DNAJA1
Tchem
Novelty: 0.00894126
p_int: 0.999778276
p_ni: 0.000205877
p_wrong: 0.000015847
Score: 0.332
Data Source: BioPlex,STRINGDB
CFAP36
Tdark
Novelty: 0.42842118
p_int: 0.998945984
p_ni: 0.001054014
p_wrong: 2e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
WRAP73
Tbio
Novelty: 0.25394934
p_int: 0.997186749
p_ni: 0.002813243
p_wrong: 8e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
ISCA2
Tbio
Novelty: 0.02194373
p_int: 0.995060285
p_ni: 0.003391202
p_wrong: 0.001548513
Data Source: BioPlex
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.972445347
p_ni: 0.024308528
p_wrong: 0.003246125
Score: 0.153
Data Source: BioPlex,STRINGDB
ZBTB37
Tdark
Family: TF
Novelty: 1.0414887
Score: 0.788
Data Source: STRINGDB
DARS2
Tbio
Family: Enzyme
Novelty: 0.01588438
Score: 0.692
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.41

PubMed score by year
PubTator Score  7.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer