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Tbio
ZNF382
Zinc finger protein 382

Protein Summary
Description
Functions as a sequence-specific transcriptional repressor. This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292928
  • ENSP00000292928
  • ENSG00000161298
  • ENST00000435416
  • ENSP00000410113
  • ENST00000439428
  • ENSP00000407593

Symbol
  • KS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
microRNA
0.62
protein domain
0.58
biological process
0.51
cell line
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.55   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.55   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (7)
1 – 7 of 7
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.983
Data Source: STRINGDB
LMOD1
Tbio
Novelty: 0.04769107
Score: 0.641
Data Source: STRINGDB
MAGEC2
Tbio
Novelty: 0.00556176
Score: 0.569
Data Source: STRINGDB
GIPC2
Tdark
Novelty: 0.21044026
Score: 0.477
Data Source: STRINGDB
HSPA4L
Tbio
Novelty: 0.05591399
Score: 0.428
Data Source: STRINGDB
GNA14
Tbio
Novelty: 0.0587776
Score: 0.424
Data Source: STRINGDB
CBX1
Tbio
Family: Epigenetic
Novelty: 0.00343221
Score: 0.405
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.55

PubMed score by year
PubTator Score  90.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer