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Tbio
CDK5RAP2
CDK5 regulatory subunit-associated protein 2

Protein Summary
Description
Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349780
  • ENSP00000343818
  • ENSG00000136861
  • ENST00000360190
  • ENSP00000353317

Symbol
  • CEP215
  • KIAA1633
  • C48
  • MCPH3
  • Cep215
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
histone modification site profile
0.82
biological process
0.79
cellular component
0.77
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.57   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.57   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
78.3
self reported educational attainment
1
1
1
10.4
triglyceride measurement
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
78.3
self reported educational attainment
1
10.4
triglyceride measurement
1
0.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDK5 regulatory subunit associated protein 2
VGNC:13863
464695
Macaque
CDK5 regulatory subunit associated protein 2
701442
Mouse
MGI:2384875
214444
Rat
RGD:708451
286919
Dog
CDK5 regulatory subunit associated protein 2
VGNC:39058
612705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDK5 regulatory subunit associated protein 2
Macaque
CDK5 regulatory subunit associated protein 2
Mouse
Rat
Dog
CDK5 regulatory subunit associated protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96SN8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (37)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (208)
1 – 10 of 208
C1orf87
Tbio
Novelty: 0.03162594
p_int: 0.999992953
p_ni: 0.000007047
Score: 0.313
Data Source: BioPlex,STRINGDB
LPXN
Tbio
Novelty: 0.00796678
p_int: 0.999804966
p_ni: 0.000195034
Data Source: BioPlex
FGL2
Tbio
Novelty: 0.01108434
p_int: 0.999522032
p_ni: 0.000477968
Score: 0.186
Data Source: BioPlex,STRINGDB
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00456972
p_int: 0.999365497
p_ni: 0.000634503
Score: 0.937
Data Source: BioPlex,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
p_int: 0.99817488
p_ni: 0.00182512
Score: 0.549
Data Source: BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.998001287
p_ni: 0.001998713
Score: 0.679
Data Source: BioPlex,STRINGDB
IKBIP
Tbio
Family: Enzyme
Novelty: 0.18707639
p_int: 0.98761184
p_ni: 0.01238816
Data Source: BioPlex
CTAG2
Tbio
Novelty: 0.02983879
p_int: 0.986999303
p_ni: 0.01300063
p_wrong: 6.6e-8
Data Source: BioPlex
FAM9C
Tdark
Novelty: 0.86727989
p_int: 0.985441665
p_ni: 0.014558331
p_wrong: 4e-9
Data Source: BioPlex
MLF1
Tbio
Novelty: 0.0239522
p_int: 0.975114019
p_ni: 0.024885981
Score: 0.198
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  104.57

PubMed score by year
PubTator Score  104.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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