Protein Summary
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
- ENST00000356387
- ENSP00000348752
- ENSG00000160991
- ENST00000403646
- ENSP00000385489
- ENST00000473939
- ENSP00000417928
- ENST00000478730
- ENSP00000418140
- ENST00000611770
- ENSP00000478113
- C7orf19
- CBCIP2
- TMEM142B
- CBCIP2
- C7orf19
- MEM142B
- TMEM142B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.84 | ||
histone modification site profile | 0.76 | ||
tissue sample | 0.63 | ||
microRNA | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.52 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 145 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.52 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 145 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (45)
Nearest Tclin Targets
Pathways (12)
Reactome (11)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | Cardiac conduction | ||||
Reactome | Elevation of cytosolic Ca2+ levels | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Cardiac conduction | ||||
Elevation of cytosolic Ca2+ levels | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (1)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 2 | 3 | 2 | 1.1 | 90.3 | ||||
insomnia measurement | 1 | 2 | 0 | 1 | 54.2 | ||||
circadian rhythm | 2 | 1 | 2 | 21.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
chronotype measurement | 2 | 1.1 | 90.3 | ||||
insomnia measurement | 0 | 1 | 54.2 | ||||
circadian rhythm | 2 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ORAI calcium release-activated calcium modulator 2 | 714917 | ||||||
Mouse | MGI:2443195 | 269717 | ||||||
Rat | RGD:1310213 | 304592 | ||||||
Dog | ORAI calcium release-activated calcium modulator 2 | VGNC:44138 | 608106 | |||||
Horse | ORAI calcium release-activated calcium modulator 2 | VGNC:51209 | 100060645 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ORAI calcium release-activated calcium modulator 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ORAI calcium release-activated calcium modulator 2 | |||||
Horse | ORAI calcium release-activated calcium modulator 2 | |||||
Publication Statistics
PubMed Score 34.52
PubMed score by year
PubTator Score 23.67
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
|---|