Pharos : Target Details

Tchem

Protein Summary

Description

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Uniprot Accession IDs

Gene Name

ORAI2

Ensembl ID

ENST00000356387
ENSP00000348752
ENSG00000160991
ENST00000403646
ENSP00000385489
ENST00000473939
ENSP00000417928
ENST00000478730
ENSP00000418140
ENST00000611770
ENSP00000478113

Symbol

C7orf19
CBCIP2
TMEM142B
CBCIP2
C7orf19
MEM142B
TMEM142B

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91

kinase perturbation	0.84

histone modification site profile	0.76

tissue sample	0.63

microRNA	0.62

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.52 (req: < 5)

View Publications

Gene RIFs: 12 (req: <= 3)

View Gene RIFs

Antibodies: 145 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.52 (req: >= 5)

Gene RIFs: 12 (req: > 3)

Antibodies: 145 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Active Ligands (2)

1 – 2 of 2

CM4620

GSK-7975A

Protein-Protein Interactions (45)

1 – 10 of 45

See Interactions on String-DB

STIM1

Tbio

Novelty: 0.00116516

Score: 0.996

Data Source: STRINGDB

STIM2

Tbio

Novelty: 0.00446493

Score: 0.993

Data Source: STRINGDB

ITPR3

Tchem

Family: IC

Novelty: 0.00154917

Score: 0.965

Data Source: STRINGDB

ITPR1

Tchem

Family: IC

Novelty: 0.00111834

Score: 0.964

Data Source: STRINGDB

ITPR2

Tbio

Family: IC

Novelty: 0.00619813

Score: 0.949

Data Source: STRINGDB

ORAI1

Tchem

Family: IC

Novelty: 0.00179685

Score: 0.903

Data Source: STRINGDB

ORAI3

Tbio

Novelty: 0.01551802

Score: 0.812

Data Source: STRINGDB

TRPC3

Tchem

Family: IC

Novelty: 0.00268752

Score: 0.797

Data Source: STRINGDB

TRPC1

Tbio

Family: IC

Novelty: 0.00233677

Score: 0.756

Data Source: STRINGDB

CALM3

Tclin

Novelty: 0.00461552

Score: 0.749

Data Source: STRINGDB

Pathways (12)

Reactome (11)

KEGG (1)

Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218

Reactome	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	92 targets	R-HSA-983695

Reactome	Cardiac conduction	137 targets	R-HSA-5576891

Reactome	Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853

Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	92 targets	R-HSA-983695

Cardiac conduction	137 targets	R-HSA-5576891

Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853

Hemostasis	666 targets	R-HSA-109582

Gene Ontology Terms (5)

Functions (1)

Components (3)

Processes (1)

Items per page:

1 – 1 of 1

GO Term	Evidence	Assigned by
store-operated calcium channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

GWAS Traits (3)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
chronotype measurement	EFO_0008328	2	3	2	1.1	90.3

insomnia measurement	EFO_0007876	1	2	0	1	54.2

circadian rhythm	EFO_0004354	2	1	2		21.5

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
chronotype measurement	EFO_0008328	2	1.1	90.3

insomnia measurement	EFO_0007876	0	1	54.2

circadian rhythm	EFO_0004354	2		21.5

Beta Count

Odds Ratio

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