You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DIRC2
Disrupted in renal carcinoma protein 2

Protein Summary
Description
Electrogenic metabolite transporter. This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261038
  • ENSP00000261038
  • ENSG00000138463

Symbol
  • RCC4
  • DIRC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.78
transcription factor binding site profile
0.7
transcription factor perturbation
0.61
transcription factor
0.6


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
78.1
calcium measurement
1
1
1
38.8
serum albumin measurement
1
1
1
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
78.1
calcium measurement
1
38.8
serum albumin measurement
1
0.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
disrupted in renal carcinoma 2
470904
Macaque
disrupted in renal carcinoma 2
720996
Mouse
MGI:2387188
224132
Rat
RGD:1310939
303902
Dog
disrupted in renal carcinoma 2
478588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
disrupted in renal carcinoma 2
Macaque
disrupted in renal carcinoma 2
Mouse
Rat
Dog
disrupted in renal carcinoma 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96SL1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (39)
1 – 10 of 39
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.936211562
p_ni:  0.000009506
p_wrong:  0.063778932
Score:  0.188
Data Source:  BioPlex,STRINGDB
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
Score:  0.724
Data Source:  STRINGDB
P2RY8
Tbio
Family:  GPCR
Novelty:  0.05574297
Score:  0.645
Data Source:  STRINGDB
HSPBAP1
Tbio
Novelty:  0.03321047
Score:  0.645
Data Source:  STRINGDB
EAF2
Tbio
Family:  TF
Novelty:  0.08392419
Score:  0.622
Data Source:  STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
Score:  0.583
Data Source:  STRINGDB
CA9
Tclin
Family:  Enzyme
Novelty:  0.00071546
Score:  0.577
Data Source:  STRINGDB
EGLN3
Tclin
Novelty:  0.00643992
Score:  0.575
Data Source:  STRINGDB
PDK1
Tchem
Family:  Kinase
Novelty:  0.0078496
Score:  0.566
Data Source:  STRINGDB
DIRC1
Tdark
Novelty:  0.53558052
Score:  0.527
Data Source:  STRINGDB
Publication Statistics
PubMed Score  37.63

PubMed score by year
PubTator Score  58.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer