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Tbio
KCTD15
BTB/POZ domain-containing protein KCTD15

Protein Classes
Protein Summary
Description
During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284006
  • ENSP00000284006
  • ENSG00000153885
  • ENST00000430256
  • ENSP00000394390
  • ENST00000588881
  • ENSP00000464812
  • ENST00000589786
  • ENSP00000467612
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
microRNA
0.89
transcription factor
0.82
PubMedID
0.77
transcription factor binding site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.77   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.77   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
13
7
15
4.2
98.4
physical activity measurement
2
3
4
35.2
body weight
1
1
0
3.7
5.4
smoking behavior
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
15
4.2
98.4
physical activity measurement
4
35.2
body weight
0
3.7
5.4
smoking behavior
1
0.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 15
VGNC:2335
455935
Macaque
potassium channel tetramerization domain containing 15
704761
Mouse
MGI:2385276
233107
Rat
RGD:1583737
499129
Dog
potassium channel tetramerization domain containing 15
VGNC:42303
484595
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 15
Macaque
potassium channel tetramerization domain containing 15
Mouse
Rat
Dog
potassium channel tetramerization domain containing 15
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96SI1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
RNA Polymerase II Transcription
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (75)
1 – 10 of 75
KCTD3
Tdark
Novelty: 0.33599775
p_int: 0.999999986
p_ni: 1.2e-8
p_wrong: 3e-9
Score: 0.273
Data Source: BioPlex,STRINGDB
NSMF
Tbio
Novelty: 0.05628346
p_int: 0.999993776
p_ni: 0.000006224
Score: 0.352
Data Source: BioPlex,STRINGDB
PRPF39
Tdark
Novelty: 0.35760414
p_int: 0.999929745
p_ni: 0.000070253
p_wrong: 2e-9
Score: 0.29
Data Source: BioPlex,STRINGDB
RUVBL2
Tbio
Novelty: 0.01129017
p_int: 0.999304045
p_ni: 0.000695923
p_wrong: 3.3e-8
Data Source: BioPlex
TMEM184A
Tbio
Novelty: 0.16408207
p_int: 0.998965741
p_ni: 0.000714181
p_wrong: 0.000320077
Score: 0.181
Data Source: BioPlex,STRINGDB
CA10
Tbio
Family: Enzyme
Novelty: 0.01053152
p_int: 0.99789956
p_ni: 0.001389496
p_wrong: 0.000710944
Score: 0.241
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.989945133
p_ni: 0.006883371
p_wrong: 0.003171495
Data Source: BioPlex
TFAP2B
Tbio
Family: TF
Novelty: 0.01383202
Score: 0.981
Data Source: Reactome,STRINGDB
TFAP2A
Tbio
Family: TF
Novelty: 0.00235655
Score: 0.978
Data Source: Reactome,STRINGDB
TFAP2E
Tbio
Family: TF
Novelty: 0.07487225
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.77

PubMed score by year
PubTator Score  9.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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