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Tbio
TBX15
T-box transcription factor TBX15

Protein Summary
Description
Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000207157
  • ENSP00000207157
  • ENSG00000092607
  • ENST00000369429
  • ENSP00000358437

Symbol
  • TBX14
  • TBX14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
gene perturbation
0.81
cell line
0.65
virus perturbation
0.64
PubMedID
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.82   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.82   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
15
30
72
99.5
waist-hip ratio
7
30
39
98.2
BMI-adjusted waist circumference
7
31
55
98.1
waist circumference
2
26
27
98
heel bone mineral density
3
4
6
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
72
99.5
waist-hip ratio
39
98.2
BMI-adjusted waist circumference
55
98.1
waist circumference
27
98
heel bone mineral density
6
95.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 15
VGNC:1664
469439
Macaque
T-box 15
712254
Mouse
MGI:1277234
21384
Dog
T-box 15
VGNC:47169
483144
Horse
T-box 15
VGNC:23930
100066709
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 15
Macaque
T-box 15
Mouse
Dog
T-box 15
Horse
T-box 15
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96SF7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (66)
1 – 10 of 66
SHOX2
Tbio
Family:  TF
Novelty:  0.01090989
Score:  0.664
Data Source:  STRINGDB
PRRX1
Tbio
Family:  TF
Novelty:  0.01218272
Score:  0.645
Data Source:  STRINGDB
PRRX2
Tbio
Family:  TF
Novelty:  0.08230504
Score:  0.624
Data Source:  STRINGDB
RPP14
Tbio
Family:  Enzyme
Novelty:  0.10813341
Score:  0.62
Data Source:  STRINGDB
WNT9B
Tbio
Novelty:  0.01146843
Score:  0.619
Data Source:  STRINGDB
WARS2
Tbio
Family:  Enzyme
Novelty:  0.0081759
Score:  0.605
Data Source:  STRINGDB
GPC4
Tbio
Novelty:  0.01319626
Score:  0.595
Data Source:  STRINGDB
MAML3
Tbio
Novelty:  0.05574812
Score:  0.594
Data Source:  STRINGDB
HOXA5
Tbio
Family:  TF
Novelty:  0.0058504
Score:  0.569
Data Source:  STRINGDB
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
Score:  0.567
Data Source:  STRINGDB
Publication Statistics
PubMed Score  34.82

PubMed score by year
PubTator Score  14.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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