Protein Summary
Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation ...more
- ENST00000357717
- ENSP00000350349
- ENSG00000152457
- ENST00000378246
- ENSP00000367492
- ENST00000378249
- ENSP00000367496
- ENST00000378254
- ENSP00000367502
- ENST00000378255
- ENSP00000367503
- ENST00000378258
- ENSP00000367506
- ENST00000378278
- ENSP00000367527
- ENST00000378289
- ENSP00000367538
- ENST00000396817
- ENSP00000380030
- ARTEMIS
- ASCID
- SCIDA
- SNM1C
- SCIDA
- SNM1C
- A-SCID
- RS-SCID
- DCLREC1C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.97 | ||
transcription factor binding site profile | 0.77 | ||
biological term | 0.67 | ||
phenotype | 0.61 | ||
cell line | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.32 (req: < 5)
Gene RIFs: 61 (req: <= 3)
Antibodies: 331 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.32 (req: >= 5)
Gene RIFs: 61 (req: > 3)
Antibodies: 331 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (141)
ZSWIM8
Novelty: 0.26740136
p_int: 0.999999704
p_ni: 2.96e-7
Score: 0.2
Data Source: BioPlex,STRINGDB
TRIM26
Novelty: 0.07177119
p_int: 0.999998438
p_ni: 0.000001562
Score: 0.159
Data Source: BioPlex,STRINGDB
PRKAG2
Family: Enzyme
Novelty: 0.00741608
p_int: 0.999993833
p_ni: 0.000006167
Score: 0.813
Data Source: BioPlex,STRINGDB
ANKRD52
Family: Enzyme
Novelty: 0.14147652
p_int: 0.999990694
p_ni: 0.000009306
Score: 0.307
Data Source: BioPlex,STRINGDB
PRKAB2
Family: Enzyme
Novelty: 0.02815065
p_int: 0.999974159
p_ni: 0.000025545
p_wrong: 2.96e-7
Score: 0.699
Data Source: BioPlex,STRINGDB
PRKAB1
Family: Kinase
Novelty: 0.01610606
p_int: 0.999459195
p_ni: 0.0005408
p_wrong: 6e-9
Score: 0.747
Data Source: BioPlex,STRINGDB
PRKAA2
Family: Kinase
Novelty: 0.01795523
p_int: 0.999243183
p_ni: 0.000756817
p_wrong: 1e-9
Score: 0.833
Data Source: BioPlex,STRINGDB
SPATA20
Novelty: 0.34126403
p_int: 0.997995514
p_ni: 0.002004486
Score: 0.183
Data Source: BioPlex,STRINGDB
PRKAA1
Family: Kinase
Novelty: 0.01205826
p_int: 0.983221593
p_ni: 0.016777646
p_wrong: 7.62e-7
Score: 0.696
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (3)
KEGG (2)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | Nonhomologous End-Joining (NHEJ) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
Nonhomologous End-Joining (NHEJ) | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (5)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 2 | 2 | 63 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 63 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | DNA cross-link repair 1C | 697493 | ||||||
Mouse | MGI:2441769 | 227525 | ||||||
Dog | DNA cross-link repair 1C | VGNC:52124 | 487123 | |||||
Horse | DNA cross-link repair 1C | 100056337 | ||||||
Opossum | DNA cross-link repair 1C | 100014840 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | DNA cross-link repair 1C | |||||
Mouse | ||||||
Dog | DNA cross-link repair 1C | |||||
Horse | DNA cross-link repair 1C | |||||
Opossum | DNA cross-link repair 1C | |||||
Publication Statistics
PubMed Score 86.32
PubMed score by year
PubTator Score 37.56
PubTator score by year
Related Publications
Text Mined References (84)
GeneRif Annotations (61)
Items per page:
0 of 0
PMID | Year | Title |
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