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Tbio
DCLRE1C
Protein artemis

Protein Summary
Description
Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357717
  • ENSP00000350349
  • ENSG00000152457
  • ENST00000378246
  • ENSP00000367492
  • ENST00000378249
  • ENSP00000367496
  • ENST00000378254
  • ENSP00000367502
  • ENST00000378255
  • ENSP00000367503
  • ENST00000378258
  • ENSP00000367506
  • ENST00000378278
  • ENSP00000367527
  • ENST00000378289
  • ENSP00000367538
  • ENST00000396817
  • ENSP00000380030

Symbol
  • ARTEMIS
  • ASCID
  • SCIDA
  • SNM1C
  • SCIDA
  • SNM1C
  • A-SCID
  • RS-SCID
  • DCLREC1C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
transcription factor binding site profile
0.77
biological term
0.67
phenotype
0.61
cell line
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.32   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.32   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
63
monocyte count
1
1
1
23
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
63
monocyte count
1
23
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DNA cross-link repair 1C
697493
Mouse
MGI:2441769
227525
Dog
DNA cross-link repair 1C
VGNC:52124
487123
Horse
DNA cross-link repair 1C
100056337
Opossum
DNA cross-link repair 1C
100014840
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DNA cross-link repair 1C
Mouse
Dog
DNA cross-link repair 1C
Horse
DNA cross-link repair 1C
Opossum
DNA cross-link repair 1C
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96SD1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Nonhomologous End-Joining (NHEJ)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Nonhomologous End-Joining (NHEJ)
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (141)
1 – 10 of 141
JAKMIP1
Tbio
Family: Enzyme
Novelty: 0.09039444
p_int: 0.999999994
p_wrong: 6e-9
Data Source: BioPlex
ZSWIM8
Tdark
Novelty: 0.26740136
p_int: 0.999999704
p_ni: 2.96e-7
Score: 0.2
Data Source: BioPlex,STRINGDB
TRIM26
Tbio
Novelty: 0.07177119
p_int: 0.999998438
p_ni: 0.000001562
Score: 0.159
Data Source: BioPlex,STRINGDB
PRKAG2
Tbio
Family: Enzyme
Novelty: 0.00741608
p_int: 0.999993833
p_ni: 0.000006167
Score: 0.813
Data Source: BioPlex,STRINGDB
ANKRD52
Tbio
Family: Enzyme
Novelty: 0.14147652
p_int: 0.999990694
p_ni: 0.000009306
Score: 0.307
Data Source: BioPlex,STRINGDB
PRKAB2
Tchem
Family: Enzyme
Novelty: 0.02815065
p_int: 0.999974159
p_ni: 0.000025545
p_wrong: 2.96e-7
Score: 0.699
Data Source: BioPlex,STRINGDB
PRKAB1
Tchem
Family: Kinase
Novelty: 0.01610606
p_int: 0.999459195
p_ni: 0.0005408
p_wrong: 6e-9
Score: 0.747
Data Source: BioPlex,STRINGDB
PRKAA2
Tchem
Family: Kinase
Novelty: 0.01795523
p_int: 0.999243183
p_ni: 0.000756817
p_wrong: 1e-9
Score: 0.833
Data Source: BioPlex,STRINGDB
SPATA20
Tdark
Novelty: 0.34126403
p_int: 0.997995514
p_ni: 0.002004486
Score: 0.183
Data Source: BioPlex,STRINGDB
PRKAA1
Tclin
Family: Kinase
Novelty: 0.01205826
p_int: 0.983221593
p_ni: 0.016777646
p_wrong: 7.62e-7
Score: 0.696
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  81.32

PubMed score by year
PubTator Score  37.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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