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Tchem
SRPK1
SRSF protein kinase 1

Protein Summary
Description
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in wh ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373825
  • ENSP00000362931
  • ENSG00000096063
  • ENST00000423325
  • ENSP00000391069

Symbol
  • SFRSK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
kinase perturbation
0.95
disease perturbation
0.93
virus perturbation
0.85
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 422   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 422   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
33.5
mean corpuscular volume
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
33.5
mean corpuscular volume
1
5.9
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (127)
1 – 10 of 127
RBM27
Tdark
Novelty: 0.04875536
p_int: 0.999602517
p_ni: 0.000397482
p_wrong: 1e-9
Score: 0.444
Data Source: BioPlex,STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
p_int: 0.999531098
p_ni: 0.000468902
Score: 0.871
Data Source: BioPlex,STRINGDB
U2AF1
Tbio
Novelty: 0.01181981
p_int: 0.999138306
p_ni: 0.000861694
Score: 0.677
Data Source: BioPlex,STRINGDB
DROSHA
Tbio
Family: Enzyme
Novelty: 0.00107123
p_int: 0.995696048
p_ni: 0.004303952
Score: 0.826
Data Source: BioPlex,STRINGDB
LUC7L
Tbio
Novelty: 0.05748021
p_int: 0.994128586
p_ni: 0.005871414
Score: 0.703
Data Source: BioPlex,STRINGDB
DHX8
Tbio
Family: Enzyme
Novelty: 0.01584745
p_int: 0.993422473
p_ni: 0.006577527
Score: 0.243
Data Source: BioPlex,STRINGDB
ACIN1
Tbio
Novelty: 0.01675479
p_int: 0.993414357
p_ni: 0.006585643
Score: 0.734
Data Source: BioPlex,STRINGDB
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.981127986
p_ni: 0.018872013
Data Source: BioPlex
ZRSR2
Tbio
Novelty: 0.03449891
p_int: 0.974167449
p_ni: 0.025832551
Score: 0.246
Data Source: BioPlex,STRINGDB
RBMX2
Tbio
Novelty: 0.08867468
p_int: 0.911907614
p_ni: 0.088092366
p_wrong: 2.1e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  119.00

PubMed score by year
PubTator Score  84.89

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer