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Tbio
SERINC2
Serine incorporator 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373709
  • ENSP00000362813
  • ENSG00000168528
  • ENST00000373710
  • ENSP00000362814
  • ENST00000536384
  • ENSP00000439048
  • ENST00000536859
  • ENSP00000444307

Symbol
  • TDE2L
  • TDE2
  • TDE2L
  • FKSG84
  • PRO0899
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
transcription factor perturbation
0.74
transcription factor
0.67
cell type or tissue
0.59
molecular function
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
1
1
1
27.3
1
1
0
1.3
17.8
hematocrit
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
1
27.3
0
1.3
17.8
hematocrit
1
3.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine incorporator 2
VGNC:1540
456700
Macaque
serine incorporator 2
705303
Mouse
MGI:1919132
230779
Rat
RGD:1311396
313057
Dog
serine incorporator 2
VGNC:46020
100855498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine incorporator 2
Macaque
serine incorporator 2
Mouse
Rat
Dog
serine incorporator 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96SA4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Serine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Serine biosynthesis
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (34)
1 – 10 of 34
STOM
Tbio
Novelty:  0.00459891
p_int:  0.970169055
p_ni:  0.029830945
Score:  0.223
Data Source:  BioPlex,STRINGDB
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
p_int:  0.963895482
p_ni:  0.036104518
Score:  0.554
Data Source:  BioPlex,STRINGDB
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.915628127
p_ni:  0.084371873
Score:  0.214
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.868410134
p_ni:  0.131589865
Score:  0.338
Data Source:  BioPlex,STRINGDB
TMBIM6
Tbio
Novelty:  0.00151958
p_int:  0.839001549
p_ni:  0.160926576
p_wrong:  0.000071875
Score:  0.267
Data Source:  BioPlex,STRINGDB
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
Score:  0.69
Data Source:  STRINGDB
ZCCHC17
Tbio
Novelty:  0.06999007
Score:  0.68
Data Source:  STRINGDB
KIAA0040
Tdark
Novelty:  0.18680374
Score:  0.668
Data Source:  STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
Score:  0.626
Data Source:  STRINGDB
LAPTM5
Tbio
Novelty:  0.06809459
Score:  0.601
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.01

PubMed score by year
PubTator Score  8.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer