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Tbio
RANBP9
Ran-binding protein 9

Protein Summary
Description
May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the ki ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000011619
  • ENSP00000011619
  • ENSG00000010017

Symbol
  • RANBPM
  • BPM-L
  • BPM90
  • RANBPM
  • RanBP7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.85
kinase perturbation
0.81
virus perturbation
0.79
histone modification site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.87   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.87   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
7.7
intelligence
1
1
0
5.5
7.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
7.7
intelligence
0
5.5
7.2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
FLT3 Signaling
Immune System
Protein-Protein Interactions (123)
1 – 10 of 123
RMND5A
Tbio
Novelty: 0.01820349
p_int: 0.98865892
p_ni: 0.01134108
Score: 0.984
Data Source: BioPlex,STRINGDB
GCG
Tchem
Novelty: 0.00004879
p_int: 0.984568781
p_ni: 0.015431219
Data Source: BioPlex
PIGT
Tbio
Family: Enzyme
Novelty: 0.02539879
p_int: 0.888356465
p_ni: 0.111643535
Score: 0.687
Data Source: BioPlex,STRINGDB
IL17F
Tbio
Novelty: 0.00223549
p_int: 0.886690978
p_ni: 0.113309022
Data Source: BioPlex
PRG3
Tbio
Novelty: 0.09431986
p_int: 0.882206924
p_ni: 0.117793076
Score: 0.536
Data Source: BioPlex,STRINGDB
DDX50
Tbio
Family: Enzyme
Novelty: 0.05314506
p_int: 0.875235448
p_ni: 0.124764552
Data Source: BioPlex
BMP1
Tchem
Novelty: 0.00299518
p_int: 0.862444111
p_ni: 0.137555889
Score: 0.351
Data Source: BioPlex,STRINGDB
PRG2
Tbio
Novelty: 0.00548995
p_int: 0.824131839
p_ni: 0.175868161
Score: 0.519
Data Source: BioPlex,STRINGDB
SPON1
Tbio
Novelty: 0.01071398
p_int: 0.810186229
p_ni: 0.189813771
Data Source: BioPlex
NMB
Tbio
Novelty: 0.00729571
p_int: 0.792272105
p_ni: 0.207727895
Data Source: BioPlex
Publication Statistics
PubMed Score  61.87

PubMed score by year
PubTator Score  54.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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