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Tbio
WRNIP1
ATPase WRNIP1

Protein Summary
Description
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS. Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380764
  • ENSP00000370141
  • ENSG00000124535
  • ENST00000380769
  • ENSP00000370146
  • ENST00000380771
  • ENSP00000370148
  • ENST00000380773
  • ENSP00000370150
  • ENST00000618555
  • ENSP00000477551

Symbol
  • WHIP
  • WHIP
  • bA420G6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
ligand (protein) perturbation
0.99
molecular function
0.96
interacting protein
0.93
transcription factor binding site profile
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
23
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
23
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Werner helicase interacting protein 1
VGNC:3789
462392
Macaque
Werner helicase interacting protein 1
707250
Mouse
MGI:1926153
78903
Rat
RGD:628836
282835
Dog
Werner helicase interacting protein 1
VGNC:48434
478698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Werner helicase interacting protein 1
Macaque
Werner helicase interacting protein 1
Mouse
Rat
Dog
Werner helicase interacting protein 1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (74)
1 – 10 of 74
WRN
Tbio
Family: Enzyme
Novelty: 0.00163164
Score: 0.97
Data Source: STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00519213
Score: 0.955
Data Source: STRINGDB
BLM
Tchem
Novelty: 0.00662454
Score: 0.881
Data Source: STRINGDB
FGFR1OP
Tbio
Novelty: 0.09922864
Score: 0.7
Data Source: STRINGDB
ATMIN
Tbio
Novelty: 0.07523218
Score: 0.693
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.683
Data Source: STRINGDB
HLTF
Tbio
Family: Enzyme
Novelty: 0.01177896
Score: 0.682
Data Source: STRINGDB
TRIR
Tdark
Novelty: 0.07839275
Score: 0.666
Data Source: STRINGDB
MCM7
Tbio
Novelty: 0.0017984
Score: 0.661
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.659
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.28

PubMed score by year
PubTator Score  13.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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