Tbio WRNIP1 ATPase WRNIP1

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Atpase Wrnip1

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Atpase Wrnip1

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Atpase Wrnip1

Protein Summary

Description

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS. Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q96S55
• B2RDB0
• Q53EP6
• Q59ET8
• Q5W0E2
• Q5W0E4
• Q8WV26
• Q9H681
• Q9NRJ6

Gene Name

• WRNIP1

Ensembl ID

• ENST00000380764
• ENSP00000370141
• ENSG00000124535
• ENST00000380769
• ENSP00000370146
• ENST00000380771
• ENSP00000370148
• ENST00000380773
• ENSP00000370150
• ENST00000618555
• ENSP00000477551

Symbol

• WHIP
• WHIP
• bA420G6.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
ligand (protein) perturbation	0.99
molecular function	0.96
interacting protein	0.93
transcription factor binding site profile	0.87

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.54   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.54   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (19)

Functions (7)

Components (4)

Processes (8)

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
ATPase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
enzyme activator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
single-stranded DNA-dependent ATPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
DNA binding	Inferred from Electronic Annotation (IEA)	InterPro
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (74)

Explore Interacting Targets

1 – 10 of 74

• See Interactions on String-DB

WRN

Tbio

Family: Enzyme

Novelty: 0.00183623

Score: 0.97

Data Source: STRINGDB

RAD18

Tbio

Family: Enzyme

Novelty: 0.00575302

Score: 0.955

Data Source: STRINGDB

BLM

Tchem

Novelty: 0.00886045

Score: 0.881

Data Source: STRINGDB

FGFR1OP

Tbio

Novelty: 0.19993673

Score: 0.7

Data Source: STRINGDB

ATMIN

Tbio

Novelty: 0.04858019

Score: 0.693

Data Source: STRINGDB

BRCA1

Tchem

Novelty: 0.00014684

Score: 0.683

Data Source: STRINGDB

HLTF

Tbio

Family: Enzyme

Novelty: 0.01410809

Score: 0.682

Data Source: STRINGDB

TRIR

Tdark

Novelty: 0.00683605

Score: 0.666

Data Source: STRINGDB

MCM7

Tbio

Novelty: 0.00227245

Score: 0.661

Data Source: STRINGDB

TP53BP1

Tbio

Family: Epigenetic

Novelty: 0.0017892

Score: 0.659

Data Source: STRINGDB

Publication Statistics

PubMed Score  378.54

PubMed score by year

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PubTator Score  13.89

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAK

1-70

RRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPGRKGSG

70-140

KRPAAAAAAGSASPRSWDEAEAQEEEEAVGDGDGDGDADADGEDDPGHWDADAAEAATAFGASGGGRPHP

140-210

RALAAEEIRQMLQGKPLADTMRPDTLQDYFGQSKAVGQDTLLRSLLETNEIPSLILWGPPGCGKTTLAHI

210-280

IASNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTI

280-350

TLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNSSSEP

350-420

AMFIEDKAVDTLAYLSDGDARAGLNGLQLAVLARLSSRKMFCKKSGQSYSPSRVLITENDVKEGLQRSHI

420-490

LYDRAGEEHYNCISALHKSMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALTQAVA

490-560

AYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRNHQGPLPPVPLHLRNAPTRLMKDLG

560-630

YGKGYKYNPMYSEPVDQEYLPEELRGVDFFKQRRC

630-665

MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPGRKGSGKRPAAAAAAGSASPRSWDEAEAQEEEEAVGDGDGDGDADADGEDDPGHWDADAAEAATAFGASGGGRPHPRALAAEEIRQMLQGKPLADTMRPDTLQDYFGQSKAVGQDTLLRSLLETNEIPSLILWGPPGCGKTTLAHIIASNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNSSSEPAMFIEDKAVDTLAYLSDGDARAGLNGLQLAVLARLSSRKMFCKKSGQSYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKSMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALTQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRNHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQEYLPEELRGVDFFKQRRC

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
DNA damage
DNA replication
Hydrolase
Immunity