Tbio WRNIP1 ATPase WRNIP1

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Atpase Wrnip1

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Atpase Wrnip1

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Atpase Wrnip1

Protein Summary

Description

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS. Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q96S55
• B2RDB0
• Q53EP6
• Q59ET8
• Q5W0E2
• Q5W0E4
• Q8WV26
• Q9H681
• Q9NRJ6

Gene Name

• WRNIP1

Ensembl ID

• ENST00000380764
• ENSP00000370141
• ENSG00000124535
• ENST00000380769
• ENSP00000370146
• ENST00000380771
• ENSP00000370148
• ENST00000380773
• ENSP00000370150
• ENST00000618555
• ENSP00000477551

Symbol

• WHIP
• WHIP
• bA420G6.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
ligand (protein) perturbation	0.99
molecular function	0.96
interacting protein	0.93
transcription factor binding site profile	0.87

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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5

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	1	1	1		23

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	1		23

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Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Werner helicase interacting protein 1	VGNC:3789	462392
Macaque	Werner helicase interacting protein 1		707250
Mouse	Werner helicase interacting protein 1	MGI:1926153	78903
Rat	Werner helicase interacting protein 1	RGD:628836	282835
Dog	Werner helicase interacting protein 1	VGNC:48434	478698

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Werner helicase interacting protein 1
Macaque	Werner helicase interacting protein 1
Mouse	Werner helicase interacting protein 1
Rat	Werner helicase interacting protein 1
Dog	Werner helicase interacting protein 1

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (19)

Functions (7)

Components (4)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
ATPase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
enzyme activator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
single-stranded DNA-dependent ATPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
DNA binding	Inferred from Electronic Annotation (IEA)	InterPro
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (74)

Explore Interacting Targets

1 – 10 of 74

• See Interactions on String-DB

WRN

Tbio

Family: Enzyme

Novelty: 0.00163164

Score: 0.97

Data Source: STRINGDB

RAD18

Tbio

Family: Enzyme

Novelty: 0.00519213

Score: 0.955

Data Source: STRINGDB

BLM

Tchem

Novelty: 0.00662454

Score: 0.881

Data Source: STRINGDB

FGFR1OP

Tbio

Novelty: 0.09922864

Score: 0.7

Data Source: STRINGDB

ATMIN

Tbio

Novelty: 0.07523218

Score: 0.693

Data Source: STRINGDB

BRCA1

Tchem

Novelty: 0.00011146

Score: 0.683

Data Source: STRINGDB

HLTF

Tbio

Family: Enzyme

Novelty: 0.01177896

Score: 0.682

Data Source: STRINGDB

TRIR

Tdark

Novelty: 0.07839275

Score: 0.666

Data Source: STRINGDB

MCM7

Tbio

Novelty: 0.0017984

Score: 0.661

Data Source: STRINGDB

TP53BP1

Tbio

Family: Epigenetic

Novelty: 0.00131256

Score: 0.659

Data Source: STRINGDB

Publication Statistics

PubMed Score  21.28

PubMed score by year

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PubTator Score  13.89

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Acetylation
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
DNA damage
DNA replication
Hydrolase
Immunity

GWAS Trait Find Similar Targets

platelet crit

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype