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Tdark
PIGS
GPI transamidase component PIG-S

Protein Summary
Description
Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308360
  • ENSP00000309430
  • ENSG00000087111
  • ENST00000395346
  • ENSP00000378755

Symbol
  • GPIBD18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
kinase perturbation
0.76
metabolite
0.73
transcription factor perturbation
0.68
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
THY1
Tbio
Novelty:  0.00032846
p_int:  0.984350121
p_ni:  0.015649879
Data Source:  BioPlex
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.970060208
p_ni:  0.029939792
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRSS50
Tbio
Family:  Enzyme
Novelty:  0.01511883
p_int:  0.887081043
p_ni:  0.112918957
Score:  0.606
Data Source:  BioPlex,STRINGDB
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.877096151
p_ni:  0.122903849
Data Source:  BioPlex
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.872257559
p_ni:  0.127742441
Score:  0.159
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.801377561
p_ni:  0.198622439
Data Source:  BioPlex
ART4
Tbio
Family:  Enzyme
Novelty:  0.15332159
p_int:  0.757456427
p_ni:  0.242543573
Data Source:  BioPlex
TCTN3
Tdark
Novelty:  0.24504659
p_int:  0.755297187
p_ni:  0.244702813
Data Source:  BioPlex
PIGK
Tbio
Family:  Enzyme
Novelty:  0.02333499
Score:  0.999
Data Source:  STRINGDB
PIGU
Tbio
Novelty:  0.11800036
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Attachment of GPI anchor to uPAR (R-HSA-162791)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attachment of GPI anchor to uPAR
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Attachment of GPI anchor to uPAR
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
36.9
tonsillectomy risk measurement
1
1
0
1.1
24.5
urate measurement
1
1
1
21.5
insomnia measurement
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
36.9
tonsillectomy risk measurement
0
1.1
24.5
urate measurement
1
21.5
insomnia measurement
0
1.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class S
VGNC:9520
455029
Macaque
phosphatidylinositol glycan anchor biosynthesis class S
709115
Mouse
MGI:2687325
276846
Rat
RGD:1359436
303277
Dog
phosphatidylinositol glycan anchor biosynthesis class S
VGNC:44541
491170
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class S
Macaque
phosphatidylinositol glycan anchor biosynthesis class S
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class S
Publication Statistics
PubMed Score 2.64
PubMed score by year
PubTator Score 0.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title