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Tbio
TP53RK
EKC/KEOPS complex subunit TP53RK

Protein Summary
Description
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372114
  • ENSP00000361186
  • ENSG00000172315

Symbol
  • C20orf64
  • PRPK
  • PRPK
  • BUD32
  • GAMOS4
  • Nori-2
  • Nori-2p
  • dJ101A2
  • C20orf64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor binding site profile
0.79
protein domain
0.73
transcription factor
0.64
hub protein
0.63


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.93   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.93   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1918294
381406
Rat
RGD:1304911
362272
Rat
RGD:1591394
685619
Dog
TP53 regulating kinase
VGNC:47727
611235
Cow
TP53 regulating kinase
VGNC:36238
619100
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Rat
Dog
TP53 regulating kinase
Cow
TP53 regulating kinase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96S44-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
RNA Polymerase II Transcription
Regulation of TP53 Activity
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
GON7
Tdark
Novelty: 0.21994743
p_int: 0.999999501
p_ni: 4.97e-7
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
OSGEP
Tbio
Family: Enzyme
Novelty: 0.0106198
p_int: 0.999985246
p_ni: 0.000014754
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LAGE3
Tdark
Novelty: 0.02099961
p_int: 0.999945209
p_ni: 0.000054791
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
TPRKB
Tbio
Novelty: 0.1035085
p_int: 0.999936474
p_ni: 0.000063526
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NUP43
Tbio
Novelty: 0.11571309
p_int: 0.998737133
p_ni: 0.001262867
Score: 0.763
Data Source: BioPlex,STRINGDB
NELL1
Tbio
Family: Enzyme
Novelty: 0.01325888
p_int: 0.997804077
p_ni: 0.002195923
Score: 0.183
Data Source: BioPlex,STRINGDB
MBIP
Tbio
Novelty: 0.05807454
p_int: 0.984591269
p_ni: 0.015408721
p_wrong: 1e-8
Score: 0.542
Data Source: BioPlex,STRINGDB
CYTH4
Tbio
Novelty: 0.05783135
p_int: 0.973342182
p_ni: 0.026657817
Data Source: BioPlex
UBA5
Tbio
Novelty: 0.05089296
p_int: 0.961697487
p_ni: 0.038302501
p_wrong: 1.2e-8
Score: 0.216
Data Source: BioPlex,STRINGDB
COMMD10
Tbio
Novelty: 0.29057641
p_int: 0.934833093
p_ni: 0.0651665
p_wrong: 4.07e-7
Score: 0.553
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  26.93

PubMed score by year
PubTator Score  9.58

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer