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Tbio
NODAL
Nodal homolog

Protein Summary
Description
Essential for mesoderm formation and axial patterning during embryonic development. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287139
  • ENSP00000287139
  • ENSG00000156574

Symbol
  • HTX5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
0.73
biological term
0.72
PubMedID
0.7
molecular function
0.6


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.04   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.04   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nodal growth differentiation factor
VGNC:5552
466100
Macaque
nodal growth differentiation factor [Source:HGNC Symbol;Acc:HGNC:7865]
Mouse
MGI:97359
18119
Rat
RGD:1305994
294503
Dog
nodal growth differentiation factor
VGNC:43879
489028
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nodal growth differentiation factor
Macaque
nodal growth differentiation factor [Source:HGNC Symbol;Acc:HGNC:7865]
Mouse
Rat
Dog
nodal growth differentiation factor
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96S42-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (58)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of signaling by NODAL
Reactome
Signaling by NODAL
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of signaling by NODAL
Signaling by NODAL
Gene Ontology Terms (57)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (86)
1 – 10 of 86
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.86980804
p_ni:  0.128738892
p_wrong:  0.001453068
Score:  0.204
Data Source:  BioPlex,STRINGDB
TDGF1
Tbio
Novelty:  0.00527099
Score:  0.983
Data Source:  Reactome,STRINGDB
CFC1
Tbio
Novelty:  0.01787772
Score:  0.982
Data Source:  Reactome,STRINGDB
LEFTY1
Tbio
Novelty:  0.01608284
Score:  0.973
Data Source:  Reactome,STRINGDB
LEFTY2
Tbio
Novelty:  0.01038653
Score:  0.973
Data Source:  Reactome,STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
Score:  0.973
Data Source:  Reactome,STRINGDB
ACVR1B
Tchem
Family:  Kinase
Novelty:  0.00633595
Score:  0.967
Data Source:  Reactome,STRINGDB
ACVR1C
Tbio
Family:  Kinase
Novelty:  0.01675672
Score:  0.965
Data Source:  Reactome,STRINGDB
CER1
Tbio
Novelty:  0.01834422
Score:  0.964
Data Source:  Reactome,STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
Score:  0.96
Data Source:  STRINGDB
Publication Statistics
PubMed Score  98.04

PubMed score by year
PubTator Score  258.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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