Tclin SLC22A12 Solute carrier family 22 member 12

Protein Summary

Description

Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q96S37
• B7WPG1
• G3XAN7
• Q19PF7
• Q19PF8
• Q19PF9
• Q19PG0
• Q6UXW3
• Q96DT2

Gene Name

• SLC22A12

Ensembl ID

• ENST00000336464
• ENSP00000336836
• ENSG00000197891
• ENST00000377567
• ENSP00000366790
• ENST00000377572
• ENSP00000366795
• ENST00000377574
• ENSP00000366797
• ENST00000473690
• ENSP00000438437

Symbol

• OATL4
• URAT1
• RST
• OAT4L
• URAT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.72
cell type or tissue	0.61
cellular component	0.57
biological term	0.54
disease	0.49

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc22 Family Of Organic Cation And Anion Transporters / Urate Transporter / Solute Carrier Family 22 Member 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.93   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.93   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 299

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4