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Tbio
IFT140
Intraflagellar transport protein 140 homolog

Protein Summary
Description
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (PubMed:20889716, PubMed:22503633). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22503633). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361339
  • ENSP00000354895
  • ENSG00000187535
  • ENST00000426508
  • ENSP00000406012

Symbol
  • KIAA0590
  • WDTC2
  • RP80
  • MZSDS
  • SRTD9
  • WDTC2
  • gs114
  • c305C8.4
  • c380F5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
small molecule perturbation
0.78
transcription factor binding site profile
0.75
cell line
0.71
cellular component
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.75   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.75   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
IFT43
Tbio
Novelty:  0.00478274
p_int:  0.999998282
p_ni:  0.000001718
Score:  0.997
Data Source:  BioPlex,STRINGDB
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.999991783
p_ni:  0.000008216
p_wrong:  1e-9
Score:  0.978
Data Source:  BioPlex,Reactome,STRINGDB
C11orf74
Tbio
Novelty:  0.17027595
p_int:  0.999991599
p_ni:  0.000008399
p_wrong:  2e-9
Score:  0.86
Data Source:  BioPlex,STRINGDB
IFT122
Tbio
Novelty:  0.02235986
p_int:  0.999955656
p_ni:  0.000044344
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TULP2
Tbio
Family:  TF
Novelty:  0.20144336
p_int:  0.983099007
p_ni:  0.016900921
p_wrong:  7.3e-8
Score:  0.581
Data Source:  BioPlex,STRINGDB
FEZ1
Tbio
Novelty:  0.02695814
p_int:  0.932890019
p_ni:  0.067018143
p_wrong:  0.000091837
Score:  0.203
Data Source:  BioPlex,STRINGDB
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.901523407
p_ni:  0.098476307
p_wrong:  2.85e-7
Score:  0.223
Data Source:  BioPlex,STRINGDB
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.827869389
p_ni:  0.172130608
p_wrong:  4e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
IFT81
Tbio
Novelty:  0.01610195
Score:  0.996
Data Source:  STRINGDB
WDR19
Tbio
Novelty:  0.037197
Score:  0.995
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Hedgehog 'off' state
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Hedgehog 'off' state
Intraflagellar transport
Organelle biogenesis and maintenance
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
4
4
71.9
snoring measurement
2
2
1
1.1
63.8
heel bone mineral density
2
2
2
61.9
1
1
0
14
52.1
maculopapular eruption
1
1
0
14
52.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
4
71.9
snoring measurement
1
1.1
63.8
heel bone mineral density
2
61.9
0
14
52.1
maculopapular eruption
0
14
52.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 140
VGNC:5803
453819
Macaque
intraflagellar transport 140
701568
Mouse
MGI:2146906
106633
Rat
RGD:2318759
100362124
Dog
intraflagellar transport 140
490075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 140
Macaque
intraflagellar transport 140
Mouse
Rat
Dog
intraflagellar transport 140
Publication Statistics
PubMed Score 43.75
PubMed score by year
PubTator Score 15.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title