Tbio IFT140 Intraflagellar transport protein 140 homolog

Protein Summary

Description

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (PubMed:20889716, PubMed:22503633). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22503633). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q96RY7
• A2A2A8
• D3DU75
• O60332
• Q9UG52

Gene Name

• IFT140

Ensembl ID

• ENST00000361339
• ENSP00000354895
• ENSG00000187535
• ENST00000426508
• ENSP00000406012

Symbol

• KIAA0590
• WDTC2
• RP80
• MZSDS
• SRTD9
• WDTC2
• gs114
• c305C8.4
• c380F5.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
small molecule perturbation	0.78
transcription factor binding site profile	0.75
cell line	0.71
cellular component	0.68

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Intraflagellar Transport Protein 140 Homolog

DTO Classes

Protein / Cellular Structure / Intraflagellar Transport Protein 140 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.75   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.75   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0