Protein Summary
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
- ENST00000311922
- ENSP00000312150
- ENSG00000173334
- ENST00000520847
- ENSP00000429063
- C8FW
- GIG2
- TRB1
- C8FW
- GIG2
- TRB1
- GIG-2
- SKIP1
- TRB-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
transcription factor binding site profile | 0.99 | ||
biological process | 0.91 | ||
PubMedID | 0.87 | ||
transcription factor | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.16 (req: < 5)
Gene RIFs: 52 (req: <= 3)
Antibodies: 341 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.16 (req: >= 5)
Gene RIFs: 52 (req: > 3)
Antibodies: 341 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (70)
MALT1
Novelty: 0.00367231
p_int: 0.999999898
p_ni: 1e-7
p_wrong: 2e-9
Score: 0.359
Data Source: BioPlex,STRINGDB
PECR
Family: Enzyme
Novelty: 0.01550165
p_int: 0.99999989
p_ni: 1.1e-7
Score: 0.202
Data Source: BioPlex,STRINGDB
DET1
Novelty: 0.01138079
p_int: 0.99999966
p_ni: 3.4e-7
Score: 0.847
Data Source: BioPlex,STRINGDB
COP1
Family: Enzyme
Novelty: 0.10908534
p_int: 0.999997984
p_ni: 0.000002016
Score: 0.857
Data Source: BioPlex,STRINGDB
FOSL2
Family: TF
Novelty: 0.00375452
p_int: 0.999886669
p_ni: 0.000063489
p_wrong: 0.000049842
Score: 0.779
Data Source: BioPlex,STRINGDB
ISCA1
Novelty: 0.01288069
p_int: 0.998761955
p_ni: 0.001238036
p_wrong: 9e-9
Score: 0.336
Data Source: BioPlex,STRINGDB
TRIB2
Family: Kinase
Novelty: 0.02240668
p_int: 0.989059047
p_ni: 0.000010953
p_wrong: 0.01093
Score: 0.831
Data Source: BioPlex,STRINGDB
UBE2E1
Novelty: 0.04048768
p_int: 0.909383861
p_ni: 0.090556475
p_wrong: 0.000059664
Score: 0.838
Data Source: BioPlex,STRINGDB
JUNB
Family: TF
Novelty: 0.00841656
p_int: 0.902329591
p_ni: 0.000032835
p_wrong: 0.097637574
Score: 0.766
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (5)
Components (2)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (67)
Items per page:
1 – 5 of 67
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 27 | 27 | 71 | 5.9 | 99.9 | ||||
low density lipoprotein cholesterol measurement | 8 | 22 | 34 | 1.9 | 99.7 | ||||
total cholesterol measurement | 12 | 23 | 36 | 2.1 | 99.7 | ||||
apolipoprotein B measurement | 1 | 11 | 11 | 99.5 | |||||
high density lipoprotein cholesterol measurement | 13 | 13 | 31 | 98.9 | |||||
Items per page:
1 – 5 of 67
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
triglyceride measurement | 71 | 5.9 | 99.9 | ||||
low density lipoprotein cholesterol measurement | 34 | 1.9 | 99.7 | ||||
total cholesterol measurement | 36 | 2.1 | 99.7 | ||||
apolipoprotein B measurement | 11 | 99.5 | |||||
high density lipoprotein cholesterol measurement | 31 | 98.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tribbles pseudokinase 1 | VGNC:774 | 464388 | |||||
Macaque | tribbles pseudokinase 1 | 693459 | ||||||
Mouse | MGI:2443397 | 211770 | ||||||
Rat | RGD:621596 | 78969 | ||||||
Dog | tribbles pseudokinase 1 | 482039 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tribbles pseudokinase 1 | |||||
Macaque | tribbles pseudokinase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tribbles pseudokinase 1 | |||||
Publication Statistics
PubMed Score 82.16
PubMed score by year
PubTator Score 74.61
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (87)
GeneRif Annotations (52)
Items per page:
0 of 0
PMID | Year | Title |
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