Tbio TRIB1 Tribbles homolog 1

Protein Summary

Description

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).

Uniprot Accession IDs

• Q96RU8
• B4DMM6
• C5HU08
• O15180
• Q9H2Y8
• TRB-1

Gene Name

• TRIB1

Ensembl ID

• ENST00000311922
• ENSP00000312150
• ENSG00000173334
• ENST00000520847
• ENSP00000429063

Symbol

• C8FW
• GIG2
• TRB1
• C8FW
• GIG2
• TRB1
• GIG-2
• SKIP1
• TRB-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
transcription factor binding site profile	0.99
biological process	0.91
PubMedID	0.87
transcription factor	0.81

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Tribbles Homolog 1

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Trbl Family / Tribbles Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.16   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 341   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.16   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (70)

Explore Interacting Targets

1 – 10 of 70

• See Interactions on String-DB

STK40

Tbio

Family:  Kinase

Novelty:  0.10461675

p_int:  1

Score:  0.886

Data Source:  BioPlex,STRINGDB

MALT1

Tchem

Novelty:  0.00367231

p_int:  0.999999898

p_ni:  1e-7

p_wrong:  2e-9

Score:  0.359

Data Source:  BioPlex,STRINGDB

PECR

Tbio

Family:  Enzyme

Novelty:  0.01550165

p_int:  0.99999989

p_ni:  1.1e-7

Score:  0.202

Data Source:  BioPlex,STRINGDB

DET1

Tbio

Novelty:  0.01138079

p_int:  0.99999966

p_ni:  3.4e-7

Score:  0.847

Data Source:  BioPlex,STRINGDB

COP1

Tbio

Family:  Enzyme

Novelty:  0.10908534

p_int:  0.999997984

p_ni:  0.000002016

Score:  0.857

Data Source:  BioPlex,STRINGDB

FOSL2

Tbio

Family:  TF

Novelty:  0.00375452

p_int:  0.999886669

p_ni:  0.000063489

p_wrong:  0.000049842

Score:  0.779

Data Source:  BioPlex,STRINGDB

ISCA1

Tbio

Novelty:  0.01288069

p_int:  0.998761955

p_ni:  0.001238036

p_wrong:  9e-9

Score:  0.336

Data Source:  BioPlex,STRINGDB

TRIB2

Tbio

Family:  Kinase

Novelty:  0.02240668

p_int:  0.989059047

p_ni:  0.000010953

p_wrong:  0.01093

Score:  0.831

Data Source:  BioPlex,STRINGDB

UBE2E1

Tbio

Novelty:  0.04048768

p_int:  0.909383861

p_ni:  0.090556475

p_wrong:  0.000059664

Score:  0.838

Data Source:  BioPlex,STRINGDB

JUNB

Tbio

Family:  TF

Novelty:  0.00841656

p_int:  0.902329591

p_ni:  0.000032835

p_wrong:  0.097637574

Score:  0.766

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (5)

Components (2)

Processes (12)

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GO Term	Evidence	Assigned by
mitogen-activated protein kinase kinase binding	Inferred from Direct Assay (IDA)	BHF-UCL
transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein kinase inhibitor activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL
ubiquitin protein ligase binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
ubiquitin-protein transferase regulator activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (67)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 67

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	27	27	71	5.9	99.9
low density lipoprotein cholesterol measurement	EFO_0004611	8	22	34	1.9	99.7
total cholesterol measurement	EFO_0004574	12	23	36	2.1	99.7
apolipoprotein B measurement	EFO_0004615	1	11	11		99.5
high density lipoprotein cholesterol measurement	EFO_0004612	13	13	31		98.9

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	71	5.9	99.9
low density lipoprotein cholesterol measurement	EFO_0004611	34	1.9	99.7
total cholesterol measurement	EFO_0004574	36	2.1	99.7
apolipoprotein B measurement	EFO_0004615	11		99.5
high density lipoprotein cholesterol measurement	EFO_0004612	31		98.9

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Polymorphism
Protein kinase inhibitor
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
Abdominal Aortic Aneurysm
adiponectin measurement
alkaline phosphatase measurement
apolipoprotein A 1 measurement
apolipoprotein B measurement
aspartate aminotransferase measurement
basophil count
basophil percentage of granulocytes
basophil percentage of leukocytes
bilirubin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tribbles pseudokinase 1	VGNC:774	464388
Macaque	tribbles pseudokinase 1		693459
Mouse	tribbles pseudokinase 1	MGI:2443397	211770
Rat	tribbles pseudokinase 1	RGD:621596	78969
Dog	tribbles pseudokinase 1		482039

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tribbles pseudokinase 1
Macaque	tribbles pseudokinase 1
Mouse	tribbles pseudokinase 1
Rat	tribbles pseudokinase 1
Dog	tribbles pseudokinase 1

Publication Statistics

PubMed Score 82.16

PubMed score by year

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PubTator Score 74.61

PubTator score by year

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Patents

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Related Publications

Text Mined References (87)

GeneRif Annotations (52)

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PMID	Year	Title