Tbio TRIB1 Tribbles homolog 1

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Tribbles Homolog 1

Protein Summary

Description

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).

Uniprot Accession IDs

• Q96RU8
• B4DMM6
• C5HU08
• O15180
• Q9H2Y8
• TRB-1

Gene Name

• TRIB1

Ensembl ID

• ENST00000311922
• ENSP00000312150
• ENSG00000173334
• ENST00000520847
• ENSP00000429063

Symbol

• C8FW
• GIG2
• TRB1
• C8FW
• GIG2
• TRB1
• GIG-2
• SKIP1
• TRB-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
transcription factor binding site profile	0.99
biological process	0.91
PubMedID	0.87
transcription factor	0.81

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 341   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (5)

1 – 5 of 5

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (19)

Functions (5)

Components (2)

Processes (12)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
mitogen-activated protein kinase kinase binding	Inferred from Direct Assay (IDA)	BHF-UCL
transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein kinase inhibitor activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL
ubiquitin protein ligase binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
ubiquitin-protein transferase regulator activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Protein-Protein Interactions (70)

Explore Interacting Targets

1 – 10 of 70

• See Interactions on String-DB

STK40

Tbio

Family: Kinase

Novelty: 0.12287289

p_int: 1

Score: 0.886

Data Source: BioPlex,STRINGDB

MALT1

Tchem

Novelty: 0.00413584

p_int: 0.999999898

p_ni: 1e-7

p_wrong: 2e-9

Score: 0.359

Data Source: BioPlex,STRINGDB

PECR

Tbio

Family: Enzyme

Novelty: 0.01991654

p_int: 0.99999989

p_ni: 1.1e-7

Score: 0.202

Data Source: BioPlex,STRINGDB

DET1

Tbio

Novelty: 0.01807423

p_int: 0.99999966

p_ni: 3.4e-7

Score: 0.847

Data Source: BioPlex,STRINGDB

COP1

Tbio

Family: Enzyme

Novelty: 0.28704864

p_int: 0.999997984

p_ni: 0.000002016

Score: 0.857

Data Source: BioPlex,STRINGDB

FOSL2

Tbio

Family: TF

Novelty: 0.006377

p_int: 0.999886669

p_ni: 0.000063489

p_wrong: 0.000049842

Score: 0.779

Data Source: BioPlex,STRINGDB

ISCA1

Tbio

Novelty: 0.01855615

p_int: 0.998761955

p_ni: 0.001238036

p_wrong: 9e-9

Score: 0.336

Data Source: BioPlex,STRINGDB

TRIB2

Tbio

Family: Kinase

Novelty: 0.02702835

p_int: 0.989059047

p_ni: 0.000010953

p_wrong: 0.01093

Score: 0.831

Data Source: BioPlex,STRINGDB

UBE2E1

Tbio

Novelty: 0.05570885

p_int: 0.909383861

p_ni: 0.090556475

p_wrong: 0.000059664

Score: 0.838

Data Source: BioPlex,STRINGDB

JUNB

Tbio

Family: TF

Novelty: 0.01119828

p_int: 0.902329591

p_ni: 0.000032835

p_wrong: 0.097637574

Score: 0.766

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  63.63

PubMed score by year

Reset Zoom

PubTator Score  74.61

PubTator score by year

Reset Zoom

Patents

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Complete proteome
Polymorphism
Protein kinase inhibitor
Reference proteome

GWAS Trait Find Similar Targets

adiponectin measurement
albuminuria
alcohol consumption measurement
alcohol drinking
alkaline phosphatase measurement
Antithrombotic agent use measurement
aspirin use measurement
basophil count
basophil percentage of granulocytes
basophil percentage of leukocytes

MGI Phenotype Find Similar Targets

adipose tissue phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging
vision/eye phenotype