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Tbio
TRIB1
Tribbles homolog 1

Protein Summary
Description
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311922
  • ENSP00000312150
  • ENSG00000173334
  • ENST00000520847
  • ENSP00000429063

Symbol
  • C8FW
  • GIG2
  • TRB1
  • C8FW
  • GIG2
  • TRB1
  • GIG-2
  • SKIP1
  • TRB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor binding site profile
0.99
biological process
0.91
PubMedID
0.87
transcription factor
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (70)
1 – 10 of 70
STK40
Tbio
Family: Kinase
Novelty: 0.12287289
p_int: 1
Score: 0.886
Data Source: BioPlex,STRINGDB
MALT1
Tchem
Novelty: 0.00413584
p_int: 0.999999898
p_ni: 1e-7
p_wrong: 2e-9
Score: 0.359
Data Source: BioPlex,STRINGDB
PECR
Tbio
Family: Enzyme
Novelty: 0.01991654
p_int: 0.99999989
p_ni: 1.1e-7
Score: 0.202
Data Source: BioPlex,STRINGDB
DET1
Tbio
Novelty: 0.01807423
p_int: 0.99999966
p_ni: 3.4e-7
Score: 0.847
Data Source: BioPlex,STRINGDB
COP1
Tbio
Family: Enzyme
Novelty: 0.28704864
p_int: 0.999997984
p_ni: 0.000002016
Score: 0.857
Data Source: BioPlex,STRINGDB
FOSL2
Tbio
Family: TF
Novelty: 0.006377
p_int: 0.999886669
p_ni: 0.000063489
p_wrong: 0.000049842
Score: 0.779
Data Source: BioPlex,STRINGDB
ISCA1
Tbio
Novelty: 0.01855615
p_int: 0.998761955
p_ni: 0.001238036
p_wrong: 9e-9
Score: 0.336
Data Source: BioPlex,STRINGDB
TRIB2
Tbio
Family: Kinase
Novelty: 0.02702835
p_int: 0.989059047
p_ni: 0.000010953
p_wrong: 0.01093
Score: 0.831
Data Source: BioPlex,STRINGDB
UBE2E1
Tbio
Novelty: 0.05570885
p_int: 0.909383861
p_ni: 0.090556475
p_wrong: 0.000059664
Score: 0.838
Data Source: BioPlex,STRINGDB
JUNB
Tbio
Family: TF
Novelty: 0.01119828
p_int: 0.902329591
p_ni: 0.000032835
p_wrong: 0.097637574
Score: 0.766
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  63.63

PubMed score by year
PubTator Score  74.61

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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