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Tbio
TRIB1
Tribbles homolog 1

Protein Summary
Description
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311922
  • ENSP00000312150
  • ENSG00000173334
  • ENST00000520847
  • ENSP00000429063

Symbol
  • C8FW
  • GIG2
  • TRB1
  • C8FW
  • GIG2
  • TRB1
  • GIG-2
  • SKIP1
  • TRB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor binding site profile
0.99
biological process
0.91
PubMedID
0.87
transcription factor
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.16   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.16   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
STK40
Tbio
Family:  Kinase
Novelty:  0.10461675
p_int:  1
Score:  0.886
Data Source:  BioPlex,STRINGDB
MALT1
Tchem
Novelty:  0.00367231
p_int:  0.999999898
p_ni:  1e-7
p_wrong:  2e-9
Score:  0.359
Data Source:  BioPlex,STRINGDB
PECR
Tbio
Family:  Enzyme
Novelty:  0.01550165
p_int:  0.99999989
p_ni:  1.1e-7
Score:  0.202
Data Source:  BioPlex,STRINGDB
DET1
Tbio
Novelty:  0.01138079
p_int:  0.99999966
p_ni:  3.4e-7
Score:  0.847
Data Source:  BioPlex,STRINGDB
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.999997984
p_ni:  0.000002016
Score:  0.857
Data Source:  BioPlex,STRINGDB
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  0.999886669
p_ni:  0.000063489
p_wrong:  0.000049842
Score:  0.779
Data Source:  BioPlex,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.998761955
p_ni:  0.001238036
p_wrong:  9e-9
Score:  0.336
Data Source:  BioPlex,STRINGDB
TRIB2
Tbio
Family:  Kinase
Novelty:  0.02240668
p_int:  0.989059047
p_ni:  0.000010953
p_wrong:  0.01093
Score:  0.831
Data Source:  BioPlex,STRINGDB
UBE2E1
Tbio
Novelty:  0.04048768
p_int:  0.909383861
p_ni:  0.090556475
p_wrong:  0.000059664
Score:  0.838
Data Source:  BioPlex,STRINGDB
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
p_int:  0.902329591
p_ni:  0.000032835
p_wrong:  0.097637574
Score:  0.766
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (67)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
27
27
71
5.9
99.9
low density lipoprotein cholesterol measurement
8
22
34
1.9
99.7
total cholesterol measurement
12
23
36
2.1
99.7
apolipoprotein B measurement
1
11
11
99.5
high density lipoprotein cholesterol measurement
13
13
31
98.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
71
5.9
99.9
low density lipoprotein cholesterol measurement
34
1.9
99.7
total cholesterol measurement
36
2.1
99.7
apolipoprotein B measurement
11
99.5
high density lipoprotein cholesterol measurement
31
98.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tribbles pseudokinase 1
VGNC:774
464388
Macaque
tribbles pseudokinase 1
693459
Mouse
MGI:2443397
211770
Rat
RGD:621596
78969
Dog
tribbles pseudokinase 1
482039
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tribbles pseudokinase 1
Macaque
tribbles pseudokinase 1
Mouse
Rat
Dog
tribbles pseudokinase 1
Publication Statistics
PubMed Score 82.16
PubMed score by year
PubTator Score 74.61
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title