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Tbio
TRIB3
Tribbles homolog 3

Protein Summary
Description
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217233
  • ENSP00000217233
  • ENSG00000101255

Symbol
  • C20orf97
  • NIPK
  • SKIP3
  • TRB3
  • NIPK
  • SINK
  • TRB3
  • SKIP3
  • C20orf97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
gene perturbation
0.99
small molecule perturbation
0.99
PubMedID
0.93


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.52   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 525   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.52   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 525   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tribbles pseudokinase 3
VGNC:14143
745623
Macaque
tribbles pseudokinase 3
714636
Mouse
MGI:1345675
228775
Rat
RGD:708432
246273
Dog
tribbles pseudokinase 3
VGNC:47802
485819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tribbles pseudokinase 3
Macaque
tribbles pseudokinase 3
Mouse
Rat
Dog
tribbles pseudokinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96RU7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (34)
Activation of AKT2 (R-HSA-165158)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AKT2
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Costimulation by the CD28 family
Name
Explore in Pharos
Explore in Source
Activation of AKT2
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Costimulation by the CD28 family
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (86)
1 – 10 of 86
STK40
Tbio
Family: Kinase
Novelty: 0.10461675
p_int: 0.996005606
p_ni: 0.003991817
p_wrong: 0.000002577
Score: 0.879
Data Source: BioPlex,STRINGDB
COP1
Tbio
Family: Enzyme
Novelty: 0.10908534
p_int: 0.967971339
p_ni: 0.032028661
Score: 0.896
Data Source: BioPlex,STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.962
Data Source: Reactome,STRINGDB
AKT2
Tchem
Family: Kinase
Novelty: 0.00167027
Score: 0.948
Data Source: Reactome,STRINGDB
PDPK1
Tchem
Family: Kinase
Novelty: 0.00430458
Score: 0.915
Data Source: STRINGDB
AKT3
Tchem
Family: Kinase
Novelty: 0.00308931
Score: 0.915
Data Source: STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.912
Data Source: STRINGDB
PPARA
Tclin
Family: NR
Novelty: 0.00017403
Score: 0.91
Data Source: STRINGDB
FABP1
Tchem
Novelty: 0.00192691
Score: 0.909
Data Source: STRINGDB
HELZ2
Tdark
Family: Enzyme
Novelty: 0.1810765
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  151.52

PubMed score by year
PubTator Score  180.86

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer