Tbio TRIB3 Tribbles homolog 3

Protein Summary

Description

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q96RU7
• Q53GU4
• Q53ZW7
• Q6I9Y9
• Q8TAI6
• Q9H5M8
• Q9NUD2
• TRB-3

Gene Name

• TRIB3

Ensembl ID

• ENST00000217233
• ENSP00000217233
• ENSG00000101255

Symbol

• C20orf97
• NIPK
• SKIP3
• TRB3
• NIPK
• SINK
• TRB3
• SKIP3
• C20orf97

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.99
gene perturbation	0.99
small molecule perturbation	0.99
PubMedID	0.93

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Tribbles Homolog 3

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Trbl Family / Tribbles Homolog 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.51   (req: < 5)

Gene RIFs: 115   (req: <= 3)

Antibodies: 525   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.51   (req: >= 5)

Gene RIFs: 115   (req: > 3)

Antibodies: 525   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0