Protein Summary
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this p ...more
- ENST00000217233
- ENSP00000217233
- ENSG00000101255
- C20orf97
- NIPK
- SKIP3
- TRB3
- NIPK
- SINK
- TRB3
- SKIP3
- C20orf97
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
biological process | 0.99 | ||
gene perturbation | 0.99 | ||
small molecule perturbation | 0.99 | ||
PubMedID | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 187.51 (req: < 5)
Gene RIFs: 82 (req: <= 3)
Antibodies: 525 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 187.51 (req: >= 5)
Gene RIFs: 82 (req: > 3)
Antibodies: 525 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (86)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (34)
Reactome (29)
KEGG (1)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of AKT2 | ||||
Reactome | Adaptive Immune System | ||||
Reactome | CD28 co-stimulation | ||||
Reactome | CD28 dependent PI3K/Akt signaling | ||||
Reactome | Costimulation by the CD28 family | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of AKT2 | ||||
Adaptive Immune System | ||||
CD28 co-stimulation | ||||
CD28 dependent PI3K/Akt signaling | ||||
Costimulation by the CD28 family | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (7)
Components (3)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 57.3 | |||||
eosinophil count | 1 | 1 | 1 | 4.3 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 57.3 | |||||
eosinophil count | 1 | 4.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tribbles pseudokinase 3 | VGNC:14143 | 745623 | |||||
Macaque | tribbles pseudokinase 3 | 714636 | ||||||
Mouse | MGI:1345675 | 228775 | ||||||
Rat | RGD:708432 | 246273 | ||||||
Dog | tribbles pseudokinase 3 | VGNC:47802 | 485819 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tribbles pseudokinase 3 | |||||
Macaque | tribbles pseudokinase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tribbles pseudokinase 3 | |||||
Publication Statistics
PubMed Score 187.51
PubMed score by year
PubTator Score 180.86
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (103)
GeneRif Annotations (82)
Items per page:
0 of 0
PMID | Year | Title |
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