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Tbio
FNBP1
Formin-binding protein 1

Protein Summary
Description
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355681
  • ENSP00000347907
  • ENSG00000187239
  • ENST00000420781
  • ENSP00000407548
  • ENST00000446176
  • ENSP00000413625

Symbol
  • FBP17
  • KIAA0554
  • FBP17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.95
virus perturbation
0.88
transcription factor binding site profile
0.86
hub protein
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.68   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.68   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (205)
WASL
Tbio
Novelty:  0.0029314
Score:  0.988
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.984
Data Source:  STRINGDB
ITSN2
Tbio
Novelty:  0.03036854
Score:  0.984
Data Source:  STRINGDB
FCHO1
Tbio
Novelty:  0.10512826
Score:  0.979
Data Source:  STRINGDB
FCHO2
Tbio
Novelty:  0.12302279
Score:  0.978
Data Source:  STRINGDB
AMPH
Tbio
Novelty:  0.00201043
Score:  0.974
Data Source:  STRINGDB
DNM2
Tchem
Novelty:  0.00265965
Score:  0.972
Data Source:  STRINGDB
PACSIN2
Tbio
Family:  Enzyme
Novelty:  0.0250489
Score:  0.968
Data Source:  STRINGDB
DNM1
Tbio
Novelty:  0.00319082
Score:  0.966
Data Source:  STRINGDB
PACSIN1
Tbio
Family:  Enzyme
Novelty:  0.01482925
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
1
1
5.6
64.9
age at first sexual intercourse measurement
1
1
1
60.5
body mass index
3
1
3
52.7
1
1
0
1.1
35
liver fat measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
1
5.6
64.9
age at first sexual intercourse measurement
1
60.5
body mass index
3
52.7
0
1.1
35
liver fat measurement
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:109606
14269
Rat
RGD:621350
192348
Dog
formin binding protein 1
VGNC:40924
480695
Horse
formin binding protein 1
VGNC:18083
100069871
Cow
formin binding protein 1
VGNC:29059
538717
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
formin binding protein 1
Horse
formin binding protein 1
Cow
formin binding protein 1
Publication Statistics
PubMed Score 32.68
PubMed score by year
PubTator Score 16.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title