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Tbio
FNBP1
Formin-binding protein 1

Protein Summary
Description
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355681
  • ENSP00000347907
  • ENSG00000187239
  • ENST00000420781
  • ENSP00000407548
  • ENST00000446176
  • ENSP00000413625

Symbol
  • FBP17
  • KIAA0554
  • FBP17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.95
virus perturbation
0.88
transcription factor binding site profile
0.86
hub protein
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.68   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.68   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (205)
1 – 10 of 205
WASL
Tbio
Novelty: 0.00386851
Score: 0.988
Data Source: STRINGDB
ITSN1
Tbio
Novelty: 0.01483242
Score: 0.984
Data Source: STRINGDB
ITSN2
Tbio
Novelty: 0.01558254
Score: 0.984
Data Source: STRINGDB
FCHO1
Tbio
Novelty: 0.1096443
Score: 0.979
Data Source: STRINGDB
FCHO2
Tbio
Novelty: 0.21241004
Score: 0.978
Data Source: STRINGDB
AMPH
Tbio
Novelty: 0.00195854
Score: 0.974
Data Source: STRINGDB
DNM2
Tchem
Novelty: 0.00331333
Score: 0.972
Data Source: STRINGDB
PACSIN2
Tbio
Family: Enzyme
Novelty: 0.03915066
Score: 0.968
Data Source: STRINGDB
DNM1
Tbio
Novelty: 0.00197543
Score: 0.966
Data Source: STRINGDB
PACSIN1
Tbio
Family: Enzyme
Novelty: 0.01829056
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.68

PubMed score by year
PubTator Score  16.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer