Tbio FNBP1 Formin-binding protein 1

Protein Summary

Description

May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96RU3
• B7ZL12
• E9PGQ4
• O60301
• Q3MIN8
• Q5TC87
• Q5TC88
• Q6P658
• Q7LGG2
• Q9H8H8
• Q9NWD1

Gene Name

• FNBP1

Ensembl ID

• ENST00000355681
• ENSP00000347907
• ENSG00000187239
• ENST00000420781
• ENSP00000407548
• ENST00000446176
• ENSP00000413625

Symbol

• FBP17
• KIAA0554
• FBP17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
kinase perturbation	0.95
virus perturbation	0.88
transcription factor binding site profile	0.86
hub protein	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.07   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.07   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0