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Tbio
USP28
Ubiquitin carboxyl-terminal hydrolase 28

Protein Summary
Description
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000003302
  • ENSP00000003302
  • ENSG00000048028
  • ENST00000537706
  • ENSP00000445743

Symbol
  • KIAA1515
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
histone modification site profile
0.74
protein domain
0.73
transcription factor perturbation
0.68
cell line
0.66


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ARCHS4
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.96   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.96   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
54.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
54.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 28
VGNC:53187
466787
Macaque
ubiquitin specific peptidase 28
696672
Mouse
MGI:2442293
235323
Rat
RGD:1311555
315639
Dog
ubiquitin specific peptidase 28
VGNC:48186
489400
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 28
Macaque
ubiquitin specific peptidase 28
Mouse
Rat
Dog
ubiquitin specific peptidase 28
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96RU2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Protein-Protein Interactions (139)
1 – 10 of 139
MRPS7
Tbio
Novelty: 0.00153134
p_int: 0.999999997
p_ni: 3e-9
p_wrong: 1e-9
Data Source: BioPlex
TRIM23
Tbio
Family: Enzyme
Novelty: 0.12751063
p_int: 0.999999747
p_ni: 1.2e-8
p_wrong: 2.41e-7
Data Source: BioPlex
KLHL2
Tbio
Novelty: 0.07279226
p_int: 0.999998692
p_ni: 0.000001308
Score: 0.187
Data Source: BioPlex,STRINGDB
COMTD1
Tdark
Family: Enzyme
Novelty: 0.245971
p_int: 0.999998691
p_ni: 0.000001309
Score: 0.184
Data Source: BioPlex,STRINGDB
OFD1
Tbio
Novelty: 0.01032841
p_int: 0.999966742
p_ni: 0.000033258
Data Source: BioPlex
GUCY1B1
Tclin
Family: Enzyme
Novelty: 0.03618378
p_int: 0.999066041
p_ni: 0.000713466
p_wrong: 0.000220493
Data Source: BioPlex
SPPL2B
Tbio
Family: Enzyme
Novelty: 0.0274774
p_int: 0.998647711
p_ni: 0.001352289
Score: 0.309
Data Source: BioPlex,STRINGDB
USP25
Tbio
Family: Enzyme
Novelty: 0.03671706
p_int: 0.996377649
p_ni: 0.003622351
Score: 0.236
Data Source: BioPlex,STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
p_int: 0.996079847
p_ni: 0.003920151
p_wrong: 2e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
SENP2
Tbio
Family: Enzyme
Novelty: 0.17238834
p_int: 0.994741058
p_ni: 0.005258942
Score: 0.416
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  41.96

PubMed score by year
PubTator Score  29.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer