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Tbio
ERBIN
Erbin

Protein Summary
Description
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284037
  • ENSP00000284037
  • ENSG00000112851
  • ENST00000380935
  • ENSP00000370322
  • ENST00000380938
  • ENSP00000370325
  • ENST00000380943
  • ENSP00000370330
  • ENST00000506030
  • ENSP00000426632
  • ENST00000508515
  • ENSP00000422015
  • ENST00000511297
  • ENSP00000422766

Symbol
  • ERBB2IP
  • KIAA1225
  • LAP2
  • LAP2
  • ERBB2IP
  • HEL-S-78
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.25   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.25   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
erbb2 interacting protein
VGNC:11942
471527
Macaque
erbb2 interacting protein
700429
Mouse
MGI:1890169
59079
Rat
RGD:1562952
365661
Dog
erbb2 interacting protein
VGNC:40438
100856182
Species
Name
OMA
EggNOG
Inparanoid
Chimp
erbb2 interacting protein
Macaque
erbb2 interacting protein
Mouse
Rat
Dog
erbb2 interacting protein
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96RT1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Downregulation of ERBB2 signaling (R-HSA-8863795)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of ERBB2 signaling
Reactome
Signal Transduction
Reactome
Signaling by ERBB2
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Downregulation of ERBB2 signaling
Signal Transduction
Signaling by ERBB2
Signaling by Receptor Tyrosine Kinases
Protein-Protein Interactions (119)
1 – 10 of 119
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.9999995
p_ni: 5e-7
Score: 0.364
Data Source: BioPlex,STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999998867
p_ni: 0.000001133
Score: 0.462
Data Source: BioPlex,STRINGDB
AZU1
Tbio
Family: Enzyme
Novelty: 0.00267169
p_int: 0.999997903
p_ni: 0.000002097
Score: 0.217
Data Source: BioPlex,STRINGDB
IL17B
Tbio
Novelty: 0.02825795
p_int: 0.99875709
p_ni: 0.00124291
Data Source: BioPlex
HOXC4
Tbio
Family: TF
Novelty: 0.02206351
p_int: 0.996451254
p_ni: 0.003548746
Score: 0.196
Data Source: BioPlex,STRINGDB
ZNF764
Tdark
Family: TF
Novelty: 0.76308829
p_int: 0.989542859
p_ni: 0.010457141
Data Source: BioPlex
ZNF785
Tdark
Family: TF
Novelty: 0.42629766
p_int: 0.988418044
p_ni: 0.011581956
Data Source: BioPlex
ZNF517
Tdark
Family: TF
Novelty: 1.60617003
p_int: 0.987252521
p_ni: 0.012747479
Data Source: BioPlex
TRMT2A
Tbio
Family: Enzyme
Novelty: 0.15277091
p_int: 0.966166394
p_ni: 0.033833606
Data Source: BioPlex
ZNF581
Tdark
Family: TF
Novelty: 18
p_int: 0.962409058
p_ni: 0.037590942
Score: 0.18
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  82.25

PubMed score by year
PubTator Score  89.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer