Tbio ERBIN Erbin

Protein Summary

Description

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q96RT1
• A0AVR1
• B4E3F1
• B7ZLV9
• E7EQW9
• E9PCR8
• Q1RMD0
• Q86W38
• Q9NR18
• Q9NW48
• Q9ULJ5

Gene Name

• ERBIN

Ensembl ID

• ENST00000284037
• ENSP00000284037
• ENSG00000112851
• ENST00000380935
• ENSP00000370322
• ENST00000380938
• ENSP00000370325
• ENST00000380943
• ENSP00000370330
• ENST00000506030
• ENSP00000426632
• ENST00000508515
• ENSP00000422015
• ENST00000511297
• ENSP00000422766

Symbol

• ERBB2IP
• KIAA1225
• LAP2
• LAP2
• ERBB2IP
• HEL-S-78

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Related Tools

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.25   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.25   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	erbb2 interacting protein	VGNC:11942	471527
Macaque	erbb2 interacting protein		700429
Mouse	Erbb2 interacting protein	MGI:1890169	59079
Rat	erbb2 interacting protein	RGD:1562952	365661
Dog	erbb2 interacting protein	VGNC:40438	100856182

Species	Name	OMA	EggNOG	Inparanoid
Chimp	erbb2 interacting protein
Macaque	erbb2 interacting protein
Mouse	Erbb2 interacting protein
Rat	erbb2 interacting protein
Dog	erbb2 interacting protein

Protein Structure (6 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96RT1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (12)

Reactome (4)

KEGG (1)

PathwayCommons (4)

WikiPathways (3)

Downregulation of ERBB2 signaling (R-HSA-8863795)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Downregulation of ERBB2 signaling	29 targets	R-HSA-8863795
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by ERBB2	50 targets	R-HSA-1227986
Reactome	Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Name	Explore in Pharos	Explore in Source
Downregulation of ERBB2 signaling	29 targets	R-HSA-8863795
Signal Transduction	2704 targets	R-HSA-162582
Signaling by ERBB2	50 targets	R-HSA-1227986
Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Gene Ontology Terms (31)

Functions (3)

Components (12)

Processes (16)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
signaling receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
ErbB-2 class receptor binding	Traceable Author Statement (TAS)	UniProtKB
structural constituent of cytoskeleton	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (119)

Explore Interacting Targets

1 – 10 of 119

• See Interactions on String-DB

PPP1CA

Tchem

Family: Enzyme

Novelty: 0.00354658

p_int: 0.9999995

p_ni: 5e-7

Score: 0.364

Data Source: BioPlex,STRINGDB

PPP1CC

Tchem

Family: Enzyme

Novelty: 0.00465946

p_int: 0.999998867

p_ni: 0.000001133

Score: 0.462

Data Source: BioPlex,STRINGDB

AZU1

Tbio

Family: Enzyme

Novelty: 0.00267169

p_int: 0.999997903

p_ni: 0.000002097

Score: 0.217

Data Source: BioPlex,STRINGDB

IL17B

Tbio

Novelty: 0.02825795

p_int: 0.99875709

p_ni: 0.00124291

Data Source: BioPlex

HOXC4

Tbio

Family: TF

Novelty: 0.02206351

p_int: 0.996451254

p_ni: 0.003548746

Score: 0.196

Data Source: BioPlex,STRINGDB

ZNF764

Tdark

Family: TF

Novelty: 0.76308829

p_int: 0.989542859

p_ni: 0.010457141

Data Source: BioPlex

ZNF785

Tdark

Family: TF

Novelty: 0.42629766

p_int: 0.988418044

p_ni: 0.011581956

Data Source: BioPlex

ZNF517

Tdark

Family: TF

Novelty: 1.60617003

p_int: 0.987252521

p_ni: 0.012747479

Data Source: BioPlex

TRMT2A

Tbio

Family: Enzyme

Novelty: 0.15277091

p_int: 0.966166394

p_ni: 0.033833606

Data Source: BioPlex

ZNF581

Tdark

Family: TF

Novelty: 18

p_int: 0.962409058

p_ni: 0.037590942

Score: 0.18

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  82.25

PubMed score by year

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PubTator Score  89.01

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Leucine-rich repeat
Membrane
Nucleus
Phosphoprotein
Polymorphism

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
integument phenotype
nervous system phenotype