Protein Summary
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
- ENST00000284037
- ENSP00000284037
- ENSG00000112851
- ENST00000380935
- ENSP00000370322
- ENST00000380938
- ENSP00000370325
- ENST00000380943
- ENSP00000370330
- ENST00000506030
- ENSP00000426632
- ENST00000508515
- ENSP00000422015
- ENST00000511297
- ENSP00000422766
- ERBB2IP
- KIAA1225
- LAP2
- LAP2
- ERBB2IP
- HEL-S-78
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.48 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 169 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.48 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 169 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (119)
PPP1CA
Family: Enzyme
Novelty: 0.00354658
p_int: 0.9999995
p_ni: 5e-7
Score: 0.364
Data Source: BioPlex,STRINGDB
PPP1CC
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999998867
p_ni: 0.000001133
Score: 0.462
Data Source: BioPlex,STRINGDB
AZU1
Family: Enzyme
Novelty: 0.00267169
p_int: 0.999997903
p_ni: 0.000002097
Score: 0.217
Data Source: BioPlex,STRINGDB
HOXC4
Family: TF
Novelty: 0.02206351
p_int: 0.996451254
p_ni: 0.003548746
Score: 0.196
Data Source: BioPlex,STRINGDB
TRMT2A
Family: Enzyme
Novelty: 0.15277091
p_int: 0.966166394
p_ni: 0.033833606
Data Source: BioPlex
ZNF581
Family: TF
Novelty: 18
p_int: 0.962409058
p_ni: 0.037590942
Score: 0.18
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (12)
Reactome (4)
KEGG (1)
PathwayCommons (4)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Downregulation of ERBB2 signaling | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by ERBB2 | ||||
Reactome | Signaling by Receptor Tyrosine Kinases | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Downregulation of ERBB2 signaling | ||||
Signal Transduction | ||||
Signaling by ERBB2 | ||||
Signaling by Receptor Tyrosine Kinases | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (3)
Components (12)
Processes (16)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | erbb2 interacting protein | VGNC:11942 | 471527 | |||||
Macaque | erbb2 interacting protein | 700429 | ||||||
Mouse | MGI:1890169 | 59079 | ||||||
Rat | RGD:1562952 | 365661 | ||||||
Dog | erbb2 interacting protein | VGNC:40438 | 100856182 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | erbb2 interacting protein | |||||
Macaque | erbb2 interacting protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | erbb2 interacting protein | |||||
Publication Statistics
PubMed Score 86.48
PubMed score by year
PubTator Score 89.01
PubTator score by year
Related Publications
Text Mined References (56)
GeneRif Annotations (29)
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