Tbio TGS1 Trimethylguanosine synthase

Protein Summary

Description

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Uniprot Accession IDs

• Q96RS0
• A6NJQ5
• Q5GH23
• Q8TDG9
• Q96QU3
• Q9H5V3

Gene Name

• TGS1

Ensembl ID

• ENST00000260129
• ENSP00000260129
• ENSG00000137574

Symbol

• HCA137
• NCOA6IP
• PIMT
• PIMT
• PIPMT
• NCOA6IP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.93
histone modification site profile	0.88
transcription factor perturbation	0.8
pathway	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.14   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.14   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0