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Tbio
TGS1
Trimethylguanosine synthase

Protein Summary
Description
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260129
  • ENSP00000260129
  • ENSG00000137574

Symbol
  • HCA137
  • NCOA6IP
  • PIMT
  • PIMT
  • PIPMT
  • NCOA6IP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.93
histone modification site profile
0.88
transcription factor perturbation
0.8
pathway
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.21   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.21   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.645
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999993941
p_ni:  0.000006059
Score:  0.77
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.999989625
p_ni:  0.000010375
Score:  0.869
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999953599
p_ni:  0.000046401
Score:  0.99
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.999494641
p_ni:  0.000505356
p_wrong:  4e-9
Data Source:  BioPlex
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999152606
p_ni:  0.000847394
Score:  0.987
Data Source:  BioPlex,STRINGDB
RRP9
Tbio
Novelty:  0.07232317
p_int:  0.996401206
p_ni:  0.003593167
p_wrong:  0.000005627
Score:  0.173
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.995425578
p_ni:  0.004135543
p_wrong:  0.000438879
Data Source:  BioPlex
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.993877858
p_ni:  0.00612214
p_wrong:  2e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.95170517
p_ni:  0.048219114
p_wrong:  0.000075716
Score:  0.958
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Developmental Biology
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Developmental Biology
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
3
3
3
88.2
neutrophil count
3
2
3
83.7
myeloid white cell count
3
2
3
83.7
mean platelet volume
3
2
3
83.5
platelet count
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
3
88.2
neutrophil count
3
83.7
myeloid white cell count
3
83.7
mean platelet volume
3
83.5
platelet count
1
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trimethylguanosine synthase 1
VGNC:785
464182
Macaque
trimethylguanosine synthase 1
695339
Mouse
MGI:2151797
116940
Rat
RGD:1309953
312947
Dog
trimethylguanosine synthase 1
VGNC:47321
477885
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trimethylguanosine synthase 1
Macaque
trimethylguanosine synthase 1
Mouse
Rat
Dog
trimethylguanosine synthase 1
Publication Statistics
PubMed Score 31.21
PubMed score by year
PubTator Score 16.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title