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Tbio
IL4I1
L-amino-acid oxidase

Protein Summary
Description
Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity). This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341114
  • ENSP00000342557
  • ENSG00000104951
  • ENST00000391826
  • ENSP00000375702
  • ENST00000595948
  • ENSP00000472474

Symbol
  • FIG1
  • LAO
  • FIG1
  • LAAO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.73
histone modification site profile
0.72
transcription factor
0.72
cell line
0.61
tissue
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.78   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.78   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
14.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 4 induced 1
VGNC:2343
456223
Mouse
MGI:109552
14204
Rat
RGD:1304831
100360621
Dog
interleukin 4 induced 1
VGNC:41988
484371
Pig
interleukin 4 induced 1
100522257
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 4 induced 1
Mouse
Rat
Dog
interleukin 4 induced 1
Pig
interleukin 4 induced 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96RQ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Phenylalanine and tyrosine metabolism
Reactome
Phenylalanine metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Phenylalanine and tyrosine metabolism
Phenylalanine metabolism
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (108)
1 – 10 of 108
NIT2
Tbio
Family:  Enzyme
Novelty:  0.01003111
Score:  0.96
Data Source:  STRINGDB
DDO
Tchem
Family:  Enzyme
Novelty:  0.02519366
Score:  0.936
Data Source:  STRINGDB
AOC1
Tchem
Family:  Enzyme
Novelty:  0.00146464
Score:  0.911
Data Source:  STRINGDB
DDC
Tclin
Family:  Enzyme
Novelty:  0.0012284
Score:  0.911
Data Source:  STRINGDB
MAT1A
Tbio
Family:  Enzyme
Novelty:  0.00384796
Score:  0.91
Data Source:  STRINGDB
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
Score:  0.91
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.91
Data Source:  STRINGDB
HPD
Tclin
Family:  Enzyme
Novelty:  0.00515372
Score:  0.91
Data Source:  STRINGDB
MAT2A
Tchem
Family:  Enzyme
Novelty:  0.00667707
Score:  0.91
Data Source:  STRINGDB
TYR
Tclin
Family:  Enzyme
Novelty:  0.00048513
Score:  0.909
Data Source:  STRINGDB
Publication Statistics
PubMed Score  257.78

PubMed score by year
PubTator Score  1194.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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