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Tbio
ERGIC2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

Protein Summary
Description
Possible role in transport between endoplasmic reticulum and Golgi. ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360150
  • ENSP00000353270
  • ENSG00000087502

Symbol
  • ERV41
  • PTX1
  • PTX1
  • CDA14
  • Erv41
  • cd002
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.84
histone modification site profile
0.79
cellular component
0.76
interacting protein
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.08   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.08   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
73.8
low density lipoprotein cholesterol measurement
1
1
1
55.3
interleukin-27 measurement
1
2
2
43.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
73.8
low density lipoprotein cholesterol measurement
1
55.3
interleukin-27 measurement
2
43.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ERGIC and golgi 2
710837
Mouse
MGI:1914706
67456
Dog
ERGIC and golgi 2
VGNC:40451
477657
Horse
ERGIC and golgi 2
VGNC:17663
100064789
Cow
ERGIC and golgi 2
VGNC:28579
512481
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ERGIC and golgi 2
Mouse
Dog
ERGIC and golgi 2
Horse
ERGIC and golgi 2
Cow
ERGIC and golgi 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96RQ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (89)
1 – 10 of 89
ERGIC3
Tbio
Novelty: 0.11095443
p_int: 0.999997184
p_ni: 0.000002816
Score: 0.902
Data Source: BioPlex,STRINGDB
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.999920169
p_ni: 0.000079831
Data Source: BioPlex
SLC22A15
Tdark
Family: Transporter
Novelty: 0.22792289
p_int: 0.999830799
p_ni: 0.000169199
p_wrong: 2e-9
Data Source: BioPlex
ZFPL1
Tbio
Novelty: 0.1829181
p_int: 0.999439315
p_ni: 0.000560685
Score: 0.165
Data Source: BioPlex,STRINGDB
COPG1
Tbio
Novelty: 0.01331193
p_int: 0.998833609
p_ni: 0.001166391
Score: 0.47
Data Source: BioPlex,STRINGDB
VAC14
Tbio
Novelty: 0.02677738
p_int: 0.998142855
p_ni: 0.001857145
Score: 0.15
Data Source: BioPlex,STRINGDB
SLC39A8
Tbio
Family: Transporter
Novelty: 0.00923197
p_int: 0.98200704
p_ni: 0.017992951
p_wrong: 9e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
SPPL2B
Tbio
Family: Enzyme
Novelty: 0.0274774
p_int: 0.975718043
p_ni: 0.024281943
p_wrong: 1.5e-8
Data Source: BioPlex
SIL1
Tbio
Novelty: 0.00848561
p_int: 0.959209272
p_ni: 0.040733097
p_wrong: 0.000057631
Score: 0.161
Data Source: BioPlex,STRINGDB
TMEM98
Tbio
Novelty: 0.10281593
p_int: 0.939679381
p_ni: 0.059367478
p_wrong: 0.000953141
Data Source: BioPlex
Publication Statistics
PubMed Score  13.08

PubMed score by year
PubTator Score  3.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer