You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GFM1
Elongation factor G, mitochondrial

Protein Summary
Description
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264263
  • ENSP00000264263
  • ENSG00000168827
  • ENST00000486715
  • ENSP00000419038

Symbol
  • EFG
  • EFG1
  • GFM
  • EFG
  • GFM
  • EFG1
  • EFGM
  • EGF1
  • hEFG1
  • COXPD1
  • mtEF-G1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
kinase perturbation
0.91
transcription factor perturbation
0.91
transcription factor binding site profile
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.45   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.45   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (392)
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.881683414
p_ni:  0.118316586
Score:  0.619
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.860559022
p_ni:  0.139440978
Score:  0.166
Data Source:  BioPlex,STRINGDB
ECSIT
Tbio
Novelty:  0.04690184
p_int:  0.847901453
p_ni:  0.152098547
Score:  0.333
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.843558866
p_ni:  0.156441134
Score:  0.57
Data Source:  BioPlex,STRINGDB
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.803477487
p_ni:  0.196522513
Data Source:  BioPlex
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.789950129
p_ni:  0.210049871
Score:  0.987
Data Source:  BioPlex,STRINGDB
SUCLA2
Tchem
Family:  Enzyme
Novelty:  0.02029861
p_int:  0.758214625
p_ni:  0.241785375
Score:  0.475
Data Source:  BioPlex,STRINGDB
MRPS7
Tbio
Novelty:  0.00153134
Score:  0.997
Data Source:  STRINGDB
MRPS16
Tbio
Novelty:  0.24108603
Score:  0.994
Data Source:  STRINGDB
MRPS5
Tbio
Novelty:  0.11423336
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Translation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.1
47.7
systolic blood pressure
1
1
1
42.3
electrocardiography
1
1
3
21
smoking status measurement
2
1
2
21
vital capacity
1
1
1
13.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
47.7
systolic blood pressure
1
42.3
electrocardiography
3
21
smoking status measurement
2
21
vital capacity
1
13.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G elongation factor mitochondrial 1
VGNC:13003
460812
Macaque
G elongation factor mitochondrial 1
706456
Mouse
MGI:107339
28030
Rat
RGD:631396
114017
Dog
G elongation factor mitochondrial 1
VGNC:41183
477128
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G elongation factor mitochondrial 1
Macaque
G elongation factor mitochondrial 1
Mouse
Rat
Dog
G elongation factor mitochondrial 1
Publication Statistics
PubMed Score 209.45
PubMed score by year
PubTator Score 317.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title