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Tclin
KCNA7
Potassium voltage-gated channel subfamily A member 7

Protein Summary
Description
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity). Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221444
  • ENSP00000221444
  • ENSG00000104848

Symbol
  • HAK6
  • KV1.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.79
gene perturbation
0.74
ligand (chemical)
0.63
cell line
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (110)
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.969
Data Source:  STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.963
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.957
Data Source:  STRINGDB
TRPM4
Tchem
Family:  IC
Novelty:  0.00423106
Score:  0.801
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
FSHB
Tbio
Novelty:  0.00510815
Score:  0.66
Data Source:  STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
Score:  0.641
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.64
Data Source:  STRINGDB
LHB
Tbio
Novelty:  0.00196754
Score:  0.616
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
8
6
7
6.3
90.4
systolic blood pressure
2
1
2
78.8
blood protein measurement
1
1
1
78.3
human Chorionic Gonadotropin measurement
1
1
1
52.5
mean arterial pressure
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
7
6.3
90.4
systolic blood pressure
2
78.8
blood protein measurement
1
78.3
human Chorionic Gonadotropin measurement
1
52.5
mean arterial pressure
1
43.2
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96664
16495
Rat
RGD:1309632
365241
Dog
potassium voltage-gated channel subfamily A member 7 [Source:HGNC Symbol;Acc:HGNC:6226]
Cow
potassium voltage-gated channel subfamily A member 7
VGNC:30426
540492
Pig
potassium voltage-gated channel subfamily A member 7 [Source:HGNC Symbol;Acc:HGNC:6226]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
potassium voltage-gated channel subfamily A member 7 [Source:HGNC Symbol;Acc:HGNC:6226]
Cow
potassium voltage-gated channel subfamily A member 7
Pig
potassium voltage-gated channel subfamily A member 7 [Source:HGNC Symbol;Acc:HGNC:6226]
Publication Statistics
PubMed Score 13.20
PubMed score by year
PubTator Score 6.62
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title