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Tclin
KCNA7
Potassium voltage-gated channel subfamily A member 7

Protein Summary
Description
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity). Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221444
  • ENSP00000221444
  • ENSG00000104848

Symbol
  • HAK6
  • KV1.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.79
gene perturbation
0.74
ligand (chemical)
0.63
cell line
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
3
9.3
puberty onset measurement
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
3
9.3
puberty onset measurement
1
4.3
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Protein-Protein Interactions (110)
1 – 10 of 110
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.969
Data Source: STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.963
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.957
Data Source: STRINGDB
TRPM4
Tchem
Family: IC
Novelty: 0.00423106
Score: 0.801
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
FSHB
Tbio
Novelty: 0.00510815
Score: 0.66
Data Source: STRINGDB
SCN1B
Tbio
Family: IC
Novelty: 0.00910273
Score: 0.641
Data Source: STRINGDB
RPS5
Tbio
Novelty: 0.00513677
Score: 0.64
Data Source: STRINGDB
LHB
Tbio
Novelty: 0.00196754
Score: 0.616
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.05

PubMed score by year
PubTator Score  6.62

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer