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Tbio
UCN2
Urocortin-2

Protein Summary
Description
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273610
  • ENSP00000273610
  • ENSG00000145040

Symbol
  • SRP
  • URP
  • UR
  • SRP
  • URP
  • UCNI
  • UCN-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
cell type or tissue
0.82
gene perturbation
0.62
tissue
0.55
biological term
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.53   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.53   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2176375
171530
Rat
RGD:620765
170896
Dog
urocortin 2
VGNC:48109
100683848
Horse
urocortin 2 [Source:HGNC Symbol;Acc:HGNC:18414]
Cow
urocortin 2
VGNC:36638
751828
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
urocortin 2
Horse
urocortin 2 [Source:HGNC Symbol;Acc:HGNC:18414]
Cow
urocortin 2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (20)
1 – 10 of 20
CRHR2
Tbio
Family: GPCR
Novelty: 0.00245379
Score: 0.955
Data Source: Reactome,STRINGDB
UCN3
Tbio
Novelty: 0.00996251
Score: 0.92
Data Source: STRINGDB
CRHR1
Tclin
Family: GPCR
Novelty: 0.00101773
Score: 0.879
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.863
Data Source: STRINGDB
UCN
Tbio
Novelty: 0.00151712
Score: 0.861
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
Score: 0.788
Data Source: STRINGDB
CRHBP
Tbio
Novelty: 0.00726484
Score: 0.676
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.583
Data Source: STRINGDB
RANBP3
Tbio
Novelty: 0.02563424
Score: 0.572
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.571
Data Source: STRINGDB
Publication Statistics
PubMed Score  134.53

PubMed score by year
PubTator Score  69.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer