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Tbio
MED15
Mediator of RNA polymerase II transcription subunit 15

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263205
  • ENSP00000263205
  • ENSG00000099917
  • ENST00000292733
  • ENSP00000292733
  • ENST00000382974
  • ENSP00000372434

Symbol
  • ARC105
  • CTG7A
  • PCQAP
  • TIG1
  • TNRC7
  • TIG1
  • CAG7A
  • CTG7A
  • PCQAP
  • TIG-1
  • TNRC7
  • ARC105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
cell type or tissue
0.81
hub protein
0.79
small molecule perturbation
0.69
cell line
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.73   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.73   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
2
3
83.2
forced expiratory volume
1
1
1
46.1
mathematical ability
3
1
3
42.3
balding measurement
1
1
1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
3
83.2
forced expiratory volume
1
46.1
mathematical ability
3
42.3
balding measurement
1
10
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 15
VGNC:5280
470144
Macaque
mediator complex subunit 15
695807
Mouse
MGI:2137379
94112
Rat
RGD:1307560
360743
Dog
mediator complex subunit 15
VGNC:43125
608008
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 15
Macaque
mediator complex subunit 15
Mouse
Rat
Dog
mediator complex subunit 15
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96RN5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (143)
1 – 10 of 143
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  0.999990249
p_ni:  0.000009751
Score:  0.997
Data Source:  BioPlex,STRINGDB
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.999986558
p_ni:  0.000013442
Score:  0.989
Data Source:  BioPlex,STRINGDB
MED17
Tbio
Family:  Enzyme
Novelty:  0.02984503
p_int:  0.99998409
p_ni:  0.000015909
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
MED10
Tdark
Family:  Enzyme
Novelty:  0.02988632
p_int:  0.999977458
p_ni:  0.000022542
Score:  0.997
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  0.999967171
p_ni:  0.000032829
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED28
Tbio
Family:  Enzyme
Novelty:  0.00362108
p_int:  0.999965822
p_ni:  0.000034178
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.999940985
p_ni:  0.000059015
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
p_int:  0.999907599
p_ni:  0.000092401
Score:  0.997
Data Source:  BioPlex,STRINGDB
CCNC
Tbio
Novelty:  0.00585842
p_int:  0.999871976
p_ni:  0.000128024
Score:  0.994
Data Source:  BioPlex,STRINGDB
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.999637103
p_ni:  0.000362896
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  69.73

PubMed score by year
PubTator Score  29.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer