Tbio SLC26A8 Testis anion transporter 1

Protein Summary

Description

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation. This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q96RN1
• Q5JVR5
• Q812C7
• Q8TC65
• Q96MA0
• Q96PK8

Gene Name

• SLC26A8

Ensembl ID

• ENST00000355574
• ENSP00000347778
• ENSG00000112053
• ENST00000394602
• ENSP00000378100
• ENST00000490799
• ENSP00000417638

Symbol

• TAT1
• TAT1
• SPGF3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
protein domain	0.73
cell type or tissue	0.62
tissue sample	0.61
gene perturbation	0.5

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc26 Family Of Anion Exchangers / Other Slc26 Anion Exchangers / Testis Anion Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.32   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.32   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0