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Tbio
SLC26A8
Testis anion transporter 1

Protein Summary
Description
Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation. This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355574
  • ENSP00000347778
  • ENSG00000112053
  • ENST00000394602
  • ENSP00000378100
  • ENST00000490799
  • ENSP00000417638

Symbol
  • TAT1
  • TAT1
  • SPGF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.73
cell type or tissue
0.62
tissue sample
0.61
gene perturbation
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.55   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.55   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (37)
1 – 10 of 37
RACGAP1
Tbio
Family:  Enzyme
Novelty:  0.01197099
Score:  0.841
Data Source:  STRINGDB
SRPK1
Tchem
Family:  Kinase
Novelty:  0.01066655
Score:  0.765
Data Source:  STRINGDB
ANLN
Tbio
Novelty:  0.00542857
Score:  0.756
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.742
Data Source:  STRINGDB
MOCS1
Tclin
Novelty:  0.02785369
Score:  0.726
Data Source:  STRINGDB
ARMC12
Tdark
Novelty:  1.14292403
Score:  0.719
Data Source:  STRINGDB
ECT2
Tbio
Novelty:  0.00834186
Score:  0.71
Data Source:  STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
Score:  0.653
Data Source:  STRINGDB
KIF23
Tbio
Novelty:  0.00719651
Score:  0.621
Data Source:  STRINGDB
HDAC10
Tclin
Family:  Epigenetic
Novelty:  0.00976829
Score:  0.561
Data Source:  STRINGDB
Gene Ontology Terms (18)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
63.4
mean corpuscular volume
1
1
1
31.2
body height
1
1
1
30.2
BMI-adjusted waist circumference
1
1
1
21.5
diabetic foot
1
1
0
1.7
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
63.4
mean corpuscular volume
1
31.2
body height
1
30.2
BMI-adjusted waist circumference
1
21.5
diabetic foot
0
1.7
17.8
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 8
VGNC:7923
747734
Mouse
MGI:2385046
224661
Rat
RGD:1308898
309646
Dog
solute carrier family 26 member 8
VGNC:46327
474888
Horse
solute carrier family 26 member 8
VGNC:23128
100063498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 8
Mouse
Rat
Dog
solute carrier family 26 member 8
Horse
solute carrier family 26 member 8
Publication Statistics
PubMed Score 12.55
PubMed score by year
PubTator Score 110.98
PubTator score by year