You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UIMC1
BRCA1-A complex subunit RAP80

Protein Summary
Description
Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA le ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377227
  • ENSP00000366434
  • ENSG00000087206
  • ENST00000506128
  • ENSP00000427480
  • ENST00000510698
  • ENSP00000423717
  • ENST00000511320
  • ENSP00000421926

Symbol
  • RAP80
  • RXRIP110
  • RAP80
  • X2HRIP110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.97
kinase perturbation
0.97
biological process
0.81
kinase
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.57   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.57   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
7
9
27
96.7
waist-hip ratio
3
7
10
95.6
BMI-adjusted waist-hip ratio
11
6
16
95.4
body height
3
3
4
86.7
age at menopause
2
1
2
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
27
96.7
waist-hip ratio
10
95.6
BMI-adjusted waist-hip ratio
16
95.4
body height
4
86.7
age at menopause
2
81
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin interaction motif containing 1
VGNC:4219
462299
Macaque
ubiquitin interaction motif containing 1
705412
Mouse
MGI:103185
20184
Rat
RGD:1307009
290997
Dog
ubiquitin interaction motif containing 1
VGNC:48127
611298
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin interaction motif containing 1
Macaque
ubiquitin interaction motif containing 1
Mouse
Rat
Dog
ubiquitin interaction motif containing 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96RL1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Protein-Protein Interactions (139)
1 – 10 of 139
BABAM1
Tbio
Novelty:  0.03812501
p_int:  0.99999986
p_ni:  1.22e-7
p_wrong:  1.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.999999675
p_ni:  3.25e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
RIOX2
Tbio
Family:  Epigenetic
Novelty:  0.03254245
p_int:  0.992072197
p_ni:  0.007927803
Score:  0.209
Data Source:  BioPlex,STRINGDB
CDPF1
Tdark
Novelty:  0.85714286
p_int:  0.982519282
p_ni:  0.003507318
p_wrong:  0.0139734
Data Source:  BioPlex
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.973623194
p_ni:  0.025340296
p_wrong:  0.001036511
Score:  0.175
Data Source:  BioPlex,STRINGDB
ABRAXAS1
Tbio
Novelty:  0.07078408
Score:  0.999
Data Source:  Reactome,STRINGDB
BRCC3
Tbio
Family:  Enzyme
Novelty:  0.04661632
Score:  0.999
Data Source:  STRINGDB
BABAM2
Tbio
Novelty:  0.00448485
Score:  0.999
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.999
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.993
Data Source:  STRINGDB
Publication Statistics
PubMed Score  49.57

PubMed score by year
PubTator Score  44.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: