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Tbio
CITED4
Cbp/p300-interacting transactivator 4

Protein Summary
Description
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372638
  • ENSP00000361721
  • ENSG00000179862

Symbol
  • MRG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
transcription factor binding site profile
0.68
histone modification site profile
0.64
transcription factor
0.59
small molecule perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.23   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.23   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (25)
1 – 10 of 25
TFAP2A
Tbio
Family: TF
Novelty: 0.0031574
Score: 0.974
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00060382
Score: 0.96
Data Source: Reactome,STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00127032
Score: 0.954
Data Source: Reactome,STRINGDB
TFAP2C
Tbio
Family: TF
Novelty: 0.01218549
Score: 0.947
Data Source: Reactome,STRINGDB
TFAP2B
Tbio
Family: TF
Novelty: 0.01864104
Score: 0.931
Data Source: Reactome,STRINGDB
CITED2
Tbio
Novelty: 0.0088691
Score: 0.92
Data Source: STRINGDB
TFAP2E
Tbio
Family: TF
Novelty: 0.07719058
Score: 0.9
Data Source: STRINGDB
TFAP2D
Tdark
Family: TF
Novelty: 0.22326391
Score: 0.9
Data Source: STRINGDB
ZNF565
Tdark
Family: TF
Score: 0.574
Data Source: STRINGDB
SUGP1
Tbio
Novelty: 0.00769665
Score: 0.551
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.23

PubMed score by year
PubTator Score  9.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer