CIC
Protein capicua homolog
Protein Summary
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. ...more
- ENST00000575354
- ENSP00000458663
- ENSG00000079432
- KIAA0306
- MRD45
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase | 0.84 | ||
ligand (protein) perturbation | 0.83 | ||
transcription factor | 0.83 | ||
transcription factor binding site profile | 0.81 | ||
small molecule perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 95.19 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 216 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 95.19 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 216 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (42)
ATXN1
Novelty: 0.00419081
p_int: 0.999999991
p_ni: 8e-9
p_wrong: 1e-9
Score: 0.973
Data Source: BioPlex,STRINGDB
ZBTB18
Family: TF
Novelty: 0.03802355
p_int: 0.999999811
p_ni: 1.5e-8
p_wrong: 1.74e-7
Score: 0.288
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte count | 2 | 1 | 2 | 78.4 | |||||
eosinophil count | 2 | 1 | 2 | 64 | |||||
1 | 1 | 1 | 53.7 | ||||||
balding measurement | 1 | 1 | 1 | 45.7 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 39.6 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte count | 2 | 78.4 | |||||
eosinophil count | 2 | 64 | |||||
1 | 53.7 | ||||||
balding measurement | 1 | 45.7 | |||||
mean corpuscular hemoglobin concentration | 1 | 39.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | capicua transcriptional repressor | VGNC:6618 | 456073 | |||||
Mouse | MGI:1918972 | 71722 | ||||||
Rat | RGD:1310706 | 308435 | ||||||
Dog | capicua transcriptional repressor | VGNC:39270 | 484475 | |||||
Horse | capicua transcriptional repressor | VGNC:51016 | 100069673 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | capicua transcriptional repressor | |||||
Mouse | ||||||
Rat | ||||||
Dog | capicua transcriptional repressor | |||||
Horse | capicua transcriptional repressor | |||||
Publication Statistics
PubMed Score 95.19
PubMed score by year
PubTator Score 67.82
PubTator score by year
Related Publications
Text Mined References (50)
GeneRif Annotations (36)
Items per page:
0 of 0
PMID | Year | Title |
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