Protein Summary
Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).
- ENST00000275461
- ENSP00000275461
- ENSG00000146618
- BHLHA31
- NATO3
- NTWIST
- PTFB
- NATO3
- NTWIST
- N-TWIST
- bHLHa31
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.8 | ||
biological process | 0.6 | ||
cell line | 0.54 | ||
tissue | 0.54 | ||
disease | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.41 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 82 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.41 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 82 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0